198218

Sigma-Aldrich

Patent Blue VF

Dye content 50 %

Synonym(s):
Acid Blue 1, Sulfan Blue
Empirical Formula (Hill Notation):
C27H31N2NaO6S2
CAS Number:
Molecular Weight:
566.66
Colour Index Number:
42045
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.47

Quality Level

form

powder

composition

Dye content, 50%

application(s)

hematology: suitable
histology: suitable

solubility

H2O: 1 mg/mL

λmax

635 nm (2nd)
-410 nm

ε (extinction coefficient)

≥50000 at 635-641 nm in H2O
≥5300 at 408-414 nm in H2O
≥7500 at 308-314 nm in H2O

Featured Industry

Diagnostic Assay Manufacturing

storage temp.

room temp

SMILES string

[Na+].CCN(CC)c1ccc(cc1)\C(=C2/C=CC(\C=C2)=[N+](\CC)CC)c3ccc(cc3S([O-])(=O)=O)S([O-])(=O)=O

InChI

1S/C27H32N2O6S2.Na/c1-5-28(6-2)22-13-9-20(10-14-22)27(21-11-15-23(16-12-21)29(7-3)8-4)25-18-17-24(36(30,31)32)19-26(25)37(33,34)35;/h9-19H,5-8H2,1-4H3,(H-,30,31,32,33,34,35);/q;+1/p-1

InChI key

SJEYSFABYSGQBG-UHFFFAOYSA-M

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Application

Patent Blue VF has been used:
  • in combination with 99mTc phytate to detect sentinel lymph node (SLN) in early stage cervical cancer patients.
  • to detect heat shock protein (HSP) gp96 induced draining lymph nodes (LNs) in mice.
  • to detect the effect of Asn-Gly-Arg (NGR)-tumor necrosis factor (TNF) on tumor perfusion in murine model.

Packaging

25 g in glass bottle

Biochem/physiol Actions

Patent Blue VF dye is a violet colored powder. It has been used in cosmetic coloring.

storage_class_code

11 - Combustible Solids

WGK Germany

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Blue dyes in medicine--a confusing terminology.
Kathrin Scherer et al.
Contact dermatitis, 54(4), 231-232 (2006-05-03)
Sentinel lymph node detection in early cervical cancer with combination 99mTc phytate and patent blue.
Niikura H
Gynecologic Oncology, 94(2), 528-532 (2004)
Cutting Edge: Heat Shock Protein gp96
Induces Maturation and Migration of
CD11c1 Cells In Vivo
Binder R J
Journal of Immunology, 165, 6029-6035 (2000)
Benoit Ayestaray et al.
Journal of plastic, reconstructive & aesthetic surgery : JPRAS, 66(3), 382-389 (2012-12-12)
Lymphoedema supermicrosurgery is known to be difficult to perform. Lymphatic vessels are not easy to individualise, because of their small calibre (inferior to 1 mm) and their translucent appearance. Patent blue is an organic colourant, which is able to enhance...
S Zervoudis et al.
European journal of gynaecological oncology, 33(3), 304-305 (2012-08-10)
Sentinel lymph node (SLN) biopsy is a well established option for assessing axillary lymph node status in breast cancer. Several techniques have been applied so far (superficial or deeper ones). Based on anatomical features of the lymphatic drainage in the...

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