21186

Supelco

Calcium ionophore III

Selectophore, function tested

Synonym(s):
Antibiotic A 23187, Calcium Ionophore A23187, Calimycin
Empirical Formula (Hill Notation):
C29H37N3O6
CAS Number:
Molecular Weight:
523.62
Beilstein/REAXYS Number:
1096801
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NB.61

Quality Level

grade

for ion-selective electrodes

product line

Selectophore

quality

function tested

Mode of action

cell membrane | interferes

antibiotic activity spectrum

Gram-positive bacteria
fungi

storage temp.

2-8°C

SMILES string

[H][C@@]1(O[C@@]2(CC[C@@H](C)[C@@H](Cc3nc4c(C(O)=O)c(NC)ccc4o3)O2)[C@H](C)C[C@H]1C)[C@H](C)C(=O)c5ccc[nH]5

InChI

1S/C29H37N3O6/c1-15-10-11-29(17(3)13-16(2)27(38-29)18(4)26(33)20-7-6-12-31-20)37-22(15)14-23-32-25-21(36-23)9-8-19(30-5)24(25)28(34)35/h6-9,12,15-18,22,27,30-31H,10-11,13-14H2,1-5H3,(H,34,35)/t15-,16-,17-,18-,22-,27+,29+/m1/s1

InChI key

HIYAVKIYRIFSCZ-CYEMHPAKSA-N

Looking for similar products? Visit Product Comparison Guide

General description

Visit our Sensor Applications portal to learn more.
Calcium ionophore III (Calimycin;CA) is a divalent cation ionophore. It has ability to transport Ca2+ ions across membranes along a concentration gradient.

Application

CA was used in elucidating the mechanisms underlying the positive and inotropic and chronotropic ability of CA on isolated superfused guinea pig atria. It may also be used to stimulate and measure the erythrocyte Ca2+ dependent K+ channels as the K+ efflux.
Calcium ionophore III may be used in ionophore-based calcium selective conductometric microsensors for the detection of calcium ions in aqueous solutions. In NIH3T3 and rat1-fibroblast cell cultures, calcium ionophore III along with thapsigargin has been reported to increase the hepatic clock gene Per1 expression in the initial period of treatment.
Ionophore highly selective for Ca2+. Potentiates responses to NMDA but not quisqualate. In cell culture, stimulates nitric oxide production by calmodulin-dependent constitutive nitric oxide synthase.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Preparation of an optical chemical sensor for Ca2+ and Mg2+

Legal Information

Selectophore is a trademark of Sigma-Aldrich Chemie GmbH

storage_class_code

13 - Non Combustible Solids

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Multiple signaling pathways elicit circadian gene expression in cultured Rat-1 fibroblasts
Balsalobre A, et al.
Current Biology, 10(20), 1291-1294 (2000)
P Lijnen et al.
British journal of industrial medicine, 48(6), 392-398 (1991-06-01)
The effects of cadmium (Cd2+) on Na+,K(+)-ATPase in disrupted human erythrocyte membranes and on various transmembrane Na+ and K+ transport systems in intact erythrocyte suspensions were studied. Cadmium2+ inhibited the erythrocyte Na+,K(+)-ATPase enzyme with a 50% inhibition at a Cd2+...
Chronic inhibition of endoplasmic reticulum calcium-release channels and calcium-ATPase lengthens the period of hepatic clock gene Per1
Baez-Ruiz A and Diaz-Mu?oz M
Journal of circadian rhythms, 9(1), 6-6 (2011)
A new calcium-sensor based on ion-selective conductometric microsensors-membranes and features
Trebbe U, et al.
Fresenius Journal of Analytical Chemistry, 371(6), 734-739 (2001)
H M Himmel et al.
Basic research in cardiology, 83(2), 167-175 (1988-03-01)
The inotropic and chronotropic effects of the calcium ionophore A23187 (calimycin = CA) in isolated, superfused, electrically driven, auxotonically contracting left and spontaneously beating right guinea-pig atria were examined at different Ca2+ concentrations. 10(-6) to 10(-5) mol/l CA shows significantly...

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service