Calcium ionophore III

Selectophore, function tested

Antibiotic A 23187, Calcium Ionophore A23187, Calimycin
Empirical Formula (Hill Notation):
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Quality Level


for ion-selective electrodes

product line



function tested

Mode of action

cell membrane | interferes

antibiotic activity spectrum

Gram-positive bacteria

storage temp.


SMILES string




InChI key


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General description

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Calcium ionophore III (Calimycin;CA) is a divalent cation ionophore. It has ability to transport Ca2+ ions across membranes along a concentration gradient.


CA was used in elucidating the mechanisms underlying the positive and inotropic and chronotropic ability of CA on isolated superfused guinea pig atria. It may also be used to stimulate and measure the erythrocyte Ca2+ dependent K+ channels as the K+ efflux.
Calcium ionophore III may be used in ionophore-based calcium selective conductometric microsensors for the detection of calcium ions in aqueous solutions. In NIH3T3 and rat1-fibroblast cell cultures, calcium ionophore III along with thapsigargin has been reported to increase the hepatic clock gene Per1 expression in the initial period of treatment.
Ionophore highly selective for Ca2+. Potentiates responses to NMDA but not quisqualate. In cell culture, stimulates nitric oxide production by calmodulin-dependent constitutive nitric oxide synthase.


Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Preparation of an optical chemical sensor for Ca2+ and Mg2+

Legal Information

Selectophore is a trademark of Sigma-Aldrich Chemie GmbH


13 - Non Combustible Solids

WGK Germany


Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Multiple signaling pathways elicit circadian gene expression in cultured Rat-1 fibroblasts
Balsalobre A, et al.
Current Biology, 10(20), 1291-1294 (2000)
P Lijnen et al.
British journal of industrial medicine, 48(6), 392-398 (1991-06-01)
The effects of cadmium (Cd2+) on Na+,K(+)-ATPase in disrupted human erythrocyte membranes and on various transmembrane Na+ and K+ transport systems in intact erythrocyte suspensions were studied. Cadmium2+ inhibited the erythrocyte Na+,K(+)-ATPase enzyme with a 50% inhibition at a Cd2+...
Chronic inhibition of endoplasmic reticulum calcium-release channels and calcium-ATPase lengthens the period of hepatic clock gene Per1
Baez-Ruiz A and Diaz-Mu?oz M
Journal of circadian rhythms, 9(1), 6-6 (2011)
A new calcium-sensor based on ion-selective conductometric microsensors-membranes and features
Trebbe U, et al.
Fresenius Journal of Analytical Chemistry, 371(6), 734-739 (2001)
H M Himmel et al.
Basic research in cardiology, 83(2), 167-175 (1988-03-01)
The inotropic and chronotropic effects of the calcium ionophore A23187 (calimycin = CA) in isolated, superfused, electrically driven, auxotonically contracting left and spontaneously beating right guinea-pig atria were examined at different Ca2+ concentrations. 10(-6) to 10(-5) mol/l CA shows significantly...

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