Acetic anhydride

ACS reagent, ≥98.0%

Linear Formula:
CAS Number:
Molecular Weight:
Beilstein/REAXYS Number:
EC Number:
MDL number:
PubChem Substance ID:

Quality Level


ACS reagent

vapor density

3.5 (vs air)

vapor pressure

10 mmHg ( 36 °C)
4 mmHg ( 20 °C)



autoignition temp.

629 °F

expl. lim.

10.3 %


MnO4- reducers, passes test

evapn. residue


refractive index

n20/D 1.390 (lit.)


138-140 °C (lit.)


−73 °C (lit.)


H2O: slightly soluble


1.08 g/mL (lit.)

anion traces

chloride (Cl-): ≤5 ppm
phosphate (PO43-): ≤0.001%
sulfate (SO42-): ≤5 ppm

cation traces

Fe: ≤5 ppm
heavy metals: ≤2 ppm

SMILES string




InChI key


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General description

Acetic anhydride is an organic solvent. On dissolution in water it undergoes solvolysis to afford acetic acid. It is widely employed for the acetylation of various alcohols. Wacher process (starting reagent + a ketene) and Knapsack process (starting reagent = acetaldehyde) have been reported for the industrial preparation of acetic anhydride.


Acetic anhydride has been used as one of the reaction components in the preparation of:
  • 2-acetylamino-5-aminobenzenesulfonic acid
  • 3,3′-bis(sulfonato)-4,4′-bis(chloroacetamido)azobenzene (BSBCA)
  • 10-acetoxy-9-nitro-octadecanoic acid, allyl ester
  • 9-nitro-oleic acid
It may be used for acetylation of anisole over HBEA zeolite in a batch reactor.


1, 6×1, 3 kg in glass bottle
5, 100, 4×100 g in glass bottle

Signal Word


Hazard Statements

Supp Hazards


Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves


UN 1715 3(8) / PGII

WGK Germany


Flash Point(F)

120.2 °F - closed cup

Flash Point(C)

49 °C - closed cup

Acetylation of anisole by acetic anhydride over a HBEA zeolite-Origin of deactivation of the catalyst.
Rohan D, et al.
J. Catal., 177(2), 296-305 (1998)
Steven R Woodcock et al.
Free radical biology & medicine, 59, 14-26 (2012-12-04)
Nitrated fatty acids are the product of nitrogen dioxide reaction with unsaturated fatty acids. The discovery of peroxynitrite and peroxidase-induced nitration of biomolecules led to the initial reports of endogenous nitrated fatty acids. These species increase during ischemia/reperfusion, but concentrations...
Darcy C Burns et al.
Nature protocols, 2(2), 251-258 (2007-04-05)
This protocol describes a procedure for the synthesis of 3,3'-bis(sulfonato)-4,4'-bis(chloroacetamido)azobenzene (BSBCA), a water-soluble, thiol-reactive, photo-switchable cross-linker. In addition, a protocol is outlined for installing the cross-linker in an intramolecular fashion onto proteins bearing two surface-exposed Cys residues. BSBCA is designed...
David G Simmons et al.
BMC genomics, 9, 352-352 (2008-07-30)
The Prolactin (PRL) hormone gene family shows considerable variation among placental mammals. Whereas there is a single PRL gene in humans that is expressed by the pituitary, there are an additional 22 genes in mice including the placental lactogens (PL)...
Lakshmi Pillai-Kastoori et al.
PLoS genetics, 10(7), e1004491-e1004491 (2014-07-11)
Ocular coloboma is a sight-threatening malformation caused by failure of the choroid fissure to close during morphogenesis of the eye, and is frequently associated with additional anomalies, including microphthalmia and cataracts. Although Hedgehog signaling is known to play a critical...

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