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27690

Sigma-Aldrich

2,4,6-Trimethylpyridine

99% (GC), liquid, puriss. p.a.

Synonym(s):

2,4,6-Collidine, sym-Collidine

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About This Item

Empirical Formula (Hill Notation):
C8H11N
CAS Number:
108-75-8
Molecular Weight:
121.18
Beilstein/REAXYS Number:
107283
EC Number:
203-613-3
MDL number:
MFCD00006338
UNSPSC Code:
12352100
PubChem Substance ID:
57648267
NACRES:
NA.21

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Product Name

2,4,6-Trimethylpyridine, puriss. p.a., 99% (GC)

grade

puriss. p.a.

Quality Level

200

assay

99% (GC)

form

liquid

impurities

≤0.1% water

evapn. residue

≤0.1%

refractive index

n20/D 1.498 (lit.)
n20/D 1.498

bp

171-172 °C (lit.)

mp

−43 °C (lit.)

density

0.917 g/mL at 25 °C (lit.)

cation traces

Al: ≤0.5 mg/kg
Ba: ≤0.1 mg/kg
Bi: ≤0.1 mg/kg
Ca: ≤0.5 mg/kg
Cd: ≤0.05 mg/kg
Co: ≤0.02 mg/kg
Cr: ≤0.02 mg/kg
Cu: ≤0.02 mg/kg
Fe: ≤0.1 mg/kg
K: ≤0.5 mg/kg
Li: ≤0.1 mg/kg
Mg: ≤0.1 mg/kg
Mn: ≤0.02 mg/kg
Mo: ≤0.1 mg/kg
Na: ≤0.5 mg/kg
Ni: ≤0.02 mg/kg
Pb: ≤0.1 mg/kg
Sr: ≤0.1 mg/kg
Zn: ≤0.1 mg/kg

storage temp.

2-8°C

SMILES string

Cc1cc(C)nc(C)c1

InChI

1S/C8H11N/c1-6-4-7(2)9-8(3)5-6/h4-5H,1-3H3

InChI key

BWZVCCNYKMEVEX-UHFFFAOYSA-N

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This Item
1423878.2226728612
2,4,6-Trimethylpyridine puriss. p.a., 99% (GC)

Sigma-Aldrich

27690

2,4,6-Trimethylpyridine

2,4,6-Trimethylpyridine ReagentPlus®, 99%

Sigma-Aldrich

142387

2,4,6-Trimethylpyridine

2,4,6-Trimethylpyridine for synthesis

Sigma-Aldrich

8.22267

2,4,6-Trimethylpyridine

Trihexyltetradecylphosphonium bis(2,4,4-trimethylpentyl)phosphinate ≥90.0%

Sigma-Aldrich

28612

Trihexyltetradecylphosphonium bis(2,4,4-trimethylpentyl)phosphinate

assay

99% (GC)

assay

99%

assay

≥98.0% (GC)

assay

≥90.0%

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

100

refractive index

n20/D 1.498 (lit.)

refractive index

n20/D 1.498 (lit.)

refractive index

-

refractive index

-

density

0.917 g/mL at 25 °C (lit.)

density

0.917 g/mL at 25 °C (lit.)

density

0.914 g/cm3 at 20 °C

density

0.895 g/mL at 20 °C (lit.)

bp

171-172 °C (lit.)

bp

171-172 °C (lit.)

bp

170-172 °C/1013 hPa

bp

-

mp

−43 °C (lit.)

mp

−43 °C (lit.)

mp

-43 °C

mp

-

General description

2,4,6-Trimethylpyridine is a heterocyclic aromatic compound that is commonly used in dehydrohalogenation reactions. It is also used as a reaction solvent or chemical additive in organic reactions due to its basic properties.

Application

2,4,6-Trimethylpyridine can be used as a reagent:      
  • In solid-phase peptide synthesis.     
  • To synthesize trichloro(2,4,6-trimethylpyridine) Au(III) complex by reacting with HAuCl4.

Tissue fixative for electron microscopy.

pictograms

FlameSkull and crossbones
GHS02,GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

3 - Flammable liquids

wgk_germany

WGK 3

flash_point_f

131.0 °F - closed cup

flash_point_c

55 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
BCCK8709
BCCK3944
BCCM5693
BCCM5694
BCCK8240

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Assessing the acid properties of desilicated ZSM-5 by FTIR using CO and 2, 4, 6-trimethylpyridine (collidine) as molecular probes.
Holm MS, et al.
Applied Catalysis A: General, 356(1), 23-30 (2009)
Halogen complexes. III. The association of 2, 4, 6-trimethylpyridine and trifluoroiodomethane.
Larsen DW and Allred AL.
The Journal of Physical Chemistry, 69(7), 2400-2401 (1965)
zeta-Collidine as a basis for buffering fixatives.
H S BENNETT et al.
The Journal of biophysical and biochemical cytology, 6(1), 113-114 (1959-08-01)
J L Tomsig et al.
Histochemistry, 87(1), 21-25 (1987-01-01)
Rat pineal nerve endings contain a population of small and of large synaptic vesicles that are either electron lucent or have electron-dense cores. It has been reported that their osmiophilia is eliminated when collidine buffer is used in the fixation
Christa A Currie et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 824(1-2), 201-205 (2005-08-09)
Microchip capillary electrophoresis (CE), coupled with indirect fluorescence detection was investigated for estimating the pK(a) values of non-fluorescent compounds. The CE method is based on the differences in electrophoretic mobility of the analyte as a function of the pH of
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