29210

Supelco

Eucalyptol

analytical standard

Synonym(s):
1,8-Epoxy-p-menthane, 1,3,3-Trimethyl-2-oxabicyclo[2.2.2]octane, 1,8-Cineole
Empirical Formula (Hill Notation):
C10H18O
CAS Number:
Molecular Weight:
154.25
Beilstein/REAXYS Number:
105109
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24
Pricing and availability is not currently available.

Quality Level

grade

analytical standard

assay

≥99.0% (GC)

form

neat

shelf life

limited shelf life, expiry date on the label

application(s)

HPLC: suitable
gas chromatography (GC): suitable

refractive index

n20/D 1.457 (lit.)
n20/D 1.458

bp

176-177 °C (lit.)

mp

1-2 °C (lit.)

density

0.921 g/mL at 25 °C (lit.)

Featured Industry

Cleaning Products
Cosmetics
Flavors and Fragrances
Food and Beverages
Personal Care

format

neat

storage temp.

2-8°C

SMILES string

C[C@]12CC[C@H](CC1)C(C)(C)O2

InChI

1S/C10H18O/c1-9(2)8-4-6-10(3,11-9)7-5-8/h8H,4-7H2,1-3H3/t8-,10+

InChI key

WEEGYLXZBRQIMU-WAAGHKOSSA-N

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General description

Eucalyptol is a saturated monoterpene. It is a volatile oil with medicinal values naturally found in eucalyptus oil. It is a isoprenoid with 2-isoprene subunits (C10).

Application

It has been used as reference standard in densitometric HPTLC analysis for the determination of Eucalyptol from external analgesic pharmaceutical formulations.
Eucalyptol may be used as a reference standard for the determination of the analyte in:
  • Melon fruits by headspace solid-phase microextraction (HS-SPME) and gas chromatography-mass spectrometry.
  • Chrysanthemum flower by pressurized hot water extraction (PHWE) followed by headspace solid-phase microextraction (HS-SPME) and gas chromatography-mass spectrometry.
  • Pharmaceutical formulations by full evaporation technique extraction followed by capillary gas chromatography and ion-trap detection.
  • External analgesic pharmaceutical formulations by densitometric HPTLC analysis.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. 29210.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Pictograms

FlameExclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

RIDADR

UN 1993C 3 / PGIII

WGK Germany

WGK 2

Flash Point(F)

125.6 °F - closed cup

Flash Point(C)

52 °C - closed cup

Fast quantitative determination of aroma volatile constituents in melon fruits by headspace--solid-phase microextraction and gas chromatography-mass spectrometry.
Verzera A, et al.
Food Analytical Methods, 4(2), 141-149 (2011)
Volatile organic compounds determined in pharmaceutical products by full evaporation technique and capillary gas chromatography/ion-trap detection.
Schuberth, Jan
Analytical Chemistry, 68(8), 1317-1320 (1996)
Anti-inflammatory activity of 1.8-cineol (eucalyptol) in bronchial asthma: a double-blind placebo-controlled trial.
Juergens, U. R., et al.
Respiratory Medicine, 97.3, 250-256 (2003)
Gas chromatography-mass spectrometry following pressurized hot water extraction and solid-phase microextraction for quantification of eucalyptol, camphor, and borneol in Chrysanthemum flowers.
Dong L, et al.
Journal of Separation Science, 30(1), 86-89 (2007)
Sara Invitto et al.
Respiratory physiology & neurobiology, 259, 37-44 (2018-07-15)
Obstructive Sleep Apnea Syndrome (OSA) is characterized by snoring associated with repeated apnea and/or obstructive hypopnea. The nasal airways of OSA patients, measured via acoustic rhinometry, could be significantly narrower than healthy subjects and this reduced nasal structure can impair...
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