Cyclosporin A

VETRANAL®, analytical standard

Antibiotic S 7481F1, Cyclosporine
Empirical Formula (Hill Notation):
CAS Number:
Molecular Weight:
Beilstein/REAXYS Number:
MDL number:
PubChem Substance ID:

Quality Level


analytical standard

product line




shelf life

limited shelf life, expiry date on the label


HPLC: suitable
gas chromatography (GC): suitable

Featured Industry

Forensics and Toxicology
Pharmaceutical (small molecule)



SMILES string




InChI key


Gene Information

human ... PPIA(5478)

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General description

Cyclosporin A has been used to:
  • Prevent rejection of kidney and liver transplants.
  • In graft versus host disease.
  • Treatment of autoimmune diseases.
  • Treatment of Schistosomiasis.
Cyclosporin A (CsA) is a fungal metabolite, a cyclic undecapeptide. It has highly specific immunosuppressive effects with low myelotoxicity, thereby making it a valuable drug in human organ transplantation. Its immunosuppressive activity is based upon its ability to inhibit early steps of T-lymphocyte activation such as lymphokine gene transcription.


Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

A fungal metabolite possessing potent immunosuppressive properties. It inhibits the T-cell receptor signal transduction pathway via the formation of cyclosporin A−cyclophilin complex that inhibits calcineurin (protein phosphatase 2B). Inhibits nitric oxide synthesis induced by interleukin 1α, lipopolysaccharides and TNFα. Can block cytochrome c release from mitochondria.

Legal Information

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Signal Word


Hazard Statements


NONH for all modes of transport

WGK Germany


Certificate of Analysis

Certificate of Origin

Cyclosporin A specifically inhibits function of nuclear proteins involved in T cell activation.
Emmel, Elizabeth A., et al.
Science, 246 (4937), 1617-1617 (1989)
Cyclosporin A inhibits T-cell growth factor gene expression at the level of mRNA transcription.
Kronke, M., et al.
Proceedings of the National Academy of Sciences of the USA, 81 (16), 5214-5218 (1984)
R E Handschumacher et al.
Science (New York, N.Y.), 226(4674), 544-547 (1984-11-02)
Cyclophilin, a specific cytosolic binding protein responsible for the concentration of the immunosuppressant cyclosporin A by lymphoid cells, was purified to homogeneity from bovine thymocytes. Cation-exchange high-performance liquid chromatography resolved a major and minor cyclophilin species that bind cyclosporin A...
Lotte Coelmont et al.
Antimicrobial agents and chemotherapy, 53(3), 967-976 (2008-12-24)
Debio 025 is a potent inhibitor of hepatitis C virus (HCV) replication (J. Paeshuyse et al., Hepatology 43:761-770, 2006). In phase I clinical studies, monotherapy (a Debio 025 dose of 1,200 mg twice a day) resulted in a mean maximal...
Xiao-Ling Liu et al.
Bioorganic & medicinal chemistry, 16(1), 171-180 (2007-10-30)
A library of chalcones with basic functionalities were screened for inhibition of P-glycoprotein (Pgp, ABCB1) by the calcein-AM accumulation assay on MDCKII/MDR1 cells. Three members that had ring A substituted with 5-(1-ethylpiperidin-4-yl) and 2,4-dimethoxy groups were found to increase calcein-AM...

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