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Supelco

4,4′-MDI

analytical standard

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Synonym(s):
4,4′-Methylenebis(phenyl isocyanate), 4,4′-Diphenylmethane diisocyanate, 4,4′-Methylenediphenyl diisocyanate, 4,4′-MDI, Bis(4-isocyanatophenyl)methane
Linear Formula:
CH2(C6H4NCO)2
CAS Number:
Molecular Weight:
250.25
Beilstein/REAXYS Number:
797662
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

Quality Level

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

bp

200 °C/5 mmHg (lit.)

mp

42-45 °C (lit.)

density

1.18 g/mL at 25 °C (lit.)

application(s)

environmental

format

neat

storage temp.

−20°C

SMILES string

O=C=Nc1ccc(Cc2ccc(cc2)N=C=O)cc1

InChI

1S/C15H10N2O2/c18-10-16-14-5-1-12(2-6-14)9-13-3-7-15(8-4-13)17-11-19/h1-8H,9H2

InChI key

UPMLOUAZCHDJJD-UHFFFAOYSA-N

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General description

4,4′-MDI can be extensively used to make urethane elastomers and urethane coatings.
This substance is listed on the positive list of the EU regulation 10/2011 for plastics intended to come into contact with food.

Application

4,4′-MDI may be used as an analytical standard for the determination of the analyte in wastewater and air samples, and human biological samples by various chromatographic techniques.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

pictograms

Health hazardExclamation mark

signalword

Danger

Hazard Classifications

Acute Tox. 4 Inhalation - Carc. 2 - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2 Inhalation - STOT SE 3

target_organs

Respiratory system

wgk_germany

WGK 1

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Sensitive determination of airborne diisocyanates by HPLC: 4, 4?-Diphenylmethane-diisocyanate (MDI)
Schulz M and Salthammer T
Fresenius Journal of Analytical Chemistry, 362(3), 289-293 (1998)
Liquid chromatography and mass spectrometry determination of aromatic amines in hydrolysed urine from workers exposed to thermal degradation products of polyurethane
Skarping G, et al.
Chromatographia, 39(9-10), 619-623 (1994)
Hatada
Macromolecular Design of Polymeric Materials, 40 (1997)
Yan Zhu et al.
Journal of chromatography. A, 956(1-2), 215-220 (2002-07-11)
A method has been developed for the simultaneous determination of a range of aromatic amines using cation-exchange chromatography performed on a standard ion chromatography column using d.c. amperometric detection. The analytes separated were 2,4- and 2,6-toluenediamine (2,4- and 2,6-TDA), aniline
A highly sensitive high-performance liquid chromatographic procedure for the determination of isocyanates in air
Schmidtke F and Seifert B
Fresenius Journal of Analytical Chemistry, 336(8), 647-654 (1990)

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