Nitroxinil

Name: Nitroxinil
Brand: SIAL
Price: 165 USD
Availability: InStock

VETRANAL^®, analytical standard

Synonym(s):

4-Hydroxy-3-iodo-5-nitrobenzonitrile, Nitroxynil

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100 MG

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About This Item

Empirical Formula (Hill Notation):

C₇H₃IN₂O₃

CAS Number:

1689-89-0

Molecular Weight:

290.01

EC Number:

216-884-8

MDL number:

MFCD00070776

UNSPSC Code:

41116107

PubChem Substance ID:

329754805

NACRES:

NA.24

Key Documents

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grade

analytical standard

Quality Level

100

product line

VETRANAL^®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

SMILES string

Oc1c(I)cc(cc1[N+]([O-])=O)C#N

InChI

1S/C7H3IN2O3/c8-5-1-4(3-9)2-6(7(5)11)10(12)13/h1-2,11H

InChI key

SGKGVABHDAQAJO-UHFFFAOYSA-N

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This Item	34078	35391	M2523
Supelco 34088 Nitroxinil	Supelco 34078 Oxyclozanide	Supelco 35391 Triclabendazole sulfoxide	Supelco M2523 Mebendazole
grade analytical standard	grade analytical standard	grade analytical standard	grade analytical standard
format neat	format neat	format neat	format neat
product line VETRANAL^®	product line VETRANAL^®	product line VETRANAL^®	product line -
shelf life limited shelf life, expiry date on the label	shelf life limited shelf life, expiry date on the label	shelf life limited shelf life, expiry date on the label	shelf life -
technique(s) HPLC: suitable	technique(s) HPLC: suitable, gas chromatography (GC): suitable	technique(s) HPLC: suitable, gas chromatography (GC): suitable	technique(s) HPLC: suitable, gas chromatography (GC): suitable
application(s) forensics and toxicology pharmaceutical (small molecule)	application(s) forensics and toxicology pharmaceutical (small molecule)	application(s) forensics and toxicology pharmaceutical (small molecule)	application(s) forensics and toxicology pharmaceutical (small molecule)

General description

Nitroxinil is an anthelmintic agent,[1] which is also an antiparasite.[2] It is highly effective against Fasciola species and its mode of action involves uncoupling the oxidative phosphorylation in liver flukes and also reduces spermatogenesis in surviving flukes, resulting in fewer fertile eggs.[1]

Application

Nitroxinil may be used as a reference standard in the determination of nitroxinil in veterinary active pharmaceutical ingredient manufacturing and bovine kidney using reversed-phase high-performance liquid chromatography (RP-HPLC) and liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS).[3][4]

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

GHS06,GHS09

signalword

Danger

hcodes

H301,H315,H317,H319,H335,H400

pcodes

P261 - P273 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number

BCCM3495

BCCD2539

BCCB1548

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Essential Drug Data for Rational Therapy in Veterinary Practice (2014)

Efficacy of nitroxynil against Fasciola hepatica resistant to triclabendazole in a naturally infected sheep flock.

Maria Martínez-Valladares et al.

Parasitology research, 107(5), 1205-1211 (2010-08-04)

The aim of this study was to compare the efficacy of triclabendazole (TCBZ) and nitroxynil against a TCBZ-resistant Fasciola hepatica strain in a naturally infected sheep flock. The efficacies were measured by the faecal egg count reduction test. The level

[Study of plasma and hepatic hydrolysis of nitroxinil derivatives].

G Baziard-Mouysset et al.

Annales pharmaceutiques francaises, 54(5), 223-227 (1996-01-01)

Seven esters derivatives of Nitroxinil were prepared and their structures were assigned by IR and 1H-NMR spectroscopy. The rate of plasma and hepatic hydrolysis were evaluated in vitro in sheep and rabbit. In view of this profile of activity, pivaloyl

Multi-residue determination of phenolic and salicylanilide anthelmintics and related compounds in bovine kidney by liquid chromatography-tandem mass spectrometry.

Caldow M, et al.

Journal of Chromatography A, 1216(46), 8200-8205 (2009)

Evaluation of nitroxynil and closantel activity using ELISA and egg counts against Fasciola hepatica in experimentally and naturally infected cattle.

C Boulard et al.

Veterinary research, 26(4), 249-255 (1995-01-01)

The responses of cattle infected with Fasciola hepatica to treatment with nitroxynil or closantel were monitored by faecal egg counts and by ELISA assay of anti-fluke antibodies. A first trial with experimentally infected heifers showed an increase in anti-fluke antibody

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