34218

Supelco

Cefuroxime

VETRANAL®, analytical standard

Empirical Formula (Hill Notation):
C16H16N4O8S
CAS Number:
Molecular Weight:
424.39
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24
Pricing and availability is not currently available.

Quality Level

grade

analytical standard

product line

VETRANAL®

form

neat

CofA

certificate is enclosed in each package

shelf life

limited shelf life, expiry date on the label

application(s)

HPLC: suitable
gas chromatography (GC): suitable

Featured Industry

Clinical
Forensics and Toxicology
Pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

HC@12SCC(COC(N)=O)=C(N1C(=O)C@H2NC(=O)\C(=N/OC)c3ccco3)C(O)=O

InChI

1S/C16H16N4O8S/c1-26-19-9(8-3-2-4-27-8)12(21)18-10-13(22)20-11(15(23)24)7(5-28-16(17)25)6-29-14(10)20/h2-4,10,14H,5-6H2,1H3,(H2,17,25)(H,18,21)(H,23,24)/b19-9-/t10-,14-/m1/s1

InChI key

JFPVXVDWJQMJEE-IZRZKJBUSA-N

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General description

Chemical structure: ß-lactam
Cefuroxime is a new broad-spectrum cephalosporin antibiotic, with increased stability to β-lactamases. It is actively used against gram-positive organisms, including penicillinase-producing staphylococci and non-β-lactamase-producing gram-negative bacteria.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Cefuroxime may be used as a reference standard in the determination of cefuroxime in plasma samples using high-performance liquid chromatography (HPLC).(3)

Legal Information

VETRANAL is a registered trademark of Sigma-Aldrich Chemie GmbH

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Certificate of Analysis
Certificate of Origin
Till Junker et al.
Swiss medical weekly, 142, w13616-w13616 (2012-09-06)
Surgical site infections (SSI) are the most common hospital-acquired infections among surgical patients, with significant impact on patient morbidity and health care costs. The Basel SSI Cohort Study was performed to evaluate risk factors and validate current preventive measures for...
Ronit Confino-Cohen et al.
The journal of allergy and clinical immunology. In practice, 5(3), 669-675 (2017-05-10)
Penicillins are the drug family most commonly associated with hypersensitivity reactions. Current guidelines recommend negative skin tests (ST) before re-administering penicillins to patients with previous nonimmediate reactions (NIR). The objective of this study was to examine whether ST are necessary...
Sathish Srinivasan et al.
Journal of refractive surgery (Thorofare, N.J. : 1995), 35(8), 538-542 (2019-08-09)
To evaluate the posterior segment visualization in patients with small-aperture intraocular lens (IOL) implantation. In this prospective, comparative case series, 15 patients who had unilateral implantation of the small-aperture IOL in their non-dominant eyes were recruited. Their fellow eyes were...
Cefuroxime, a new cephalosporin antibiotic: activity in vitro.
O'Callaghan HC, et al.
Antimicrobial Agents and Chemotherapy, 9(3), 511-519 (1976)
T B Vree et al.
Pharmaceutisch weekblad. Scientific edition, 12(6A), 262-266 (1990-12-14)
Cefuroxime is well-absorbed and distributed over the human body. This review gives a general summary of published information on tissue concentrations of cefuroxime after an intravenous or intramuscular dose of 750 or 1,500 mg of cefuroxime. Tissue concentrations are given...

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