This product, commonly called BHT, is commonly used as an antioxidant. It has a purity specification of at least 99.0 percent as determined by gas chromatography (GC), but it probably can also be used for HPLC work. If the BHT is in the eluant, it would be recommended to perform a blank run to identify any peaks coming from the BHT. And if the BHT is being added to the samples, it would be recommended to perform a sample blank run...with BHT, but without the analyte.
34750
2,6-Di-tert-butyl-4-methylphenol
purum, ≥99.0% (GC)
2,6-Di-tert-butyl-4-methylphenol
Synonym(s):
2,6-Di-tert-butyl-p-cresol, BHT, Butylated hydroxytoluene, Butylhydroxytoluene, DBPC
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250 G
$38.70
1 KG
$97.40
$38.70
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About This Item
Linear Formula:
[(CH3)3C]2C6H2(CH3)OH
CAS Number:
Molecular Weight:
220.35
Beilstein/REAXYS Number:
1911640
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
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vapor density
7.6 (vs air)
Quality Level
vapor pressure
<0.01 mmHg ( 20 °C)
grade
purum
assay
≥99.0% (GC)
autoignition temp.
878 °F
bp
265 °C (lit.)
mp
68-72 °C
69-73 °C (lit.)
solubility
methanol: 0.1 g/mL, clear, colorless
methanol: soluble 100 mg/mL, clear, colorless
SMILES string
Cc1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C
InChI
1S/C15H24O/c1-10-8-11(14(2,3)4)13(16)12(9-10)15(5,6)7/h8-9,16H,1-7H3
Inchi Key
NLZUEZXRPGMBCV-UHFFFAOYSA-N
Gene Information
human ... CAPN1(823)
rat ... Capn1(29153), Nos1(24598)
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This Item | W218405 | 8.17074 | PHR1117 |
|---|---|---|---|
| assay ≥99.0% (GC) | assay ≥99% | assay - | assay - |
| Quality Level 200 | Quality Level 400 | Quality Level 400 | Quality Level 300 |
| solubility methanol: 0.1 g/mL, clear, colorless, methanol: soluble 100 mg/mL, clear, colorless | solubility - | solubility - | solubility - |
| bp 265 °C (lit.) | bp 265 °C (lit.) | bp 265 °C/1013 hPa | bp 265 °C (lit.) |
| mp 68-72 °C, 69-73 °C (lit.) | mp 69-73 °C (lit.) | mp 69-70 °C | mp 69-73 °C (lit.) |
| vapor density 7.6 (vs air) | vapor density 7.6 (vs air) | vapor density - | vapor density 7.6 (vs air) |
General description
2,6-Di-tert-butyl-4-methylphenol is an 4-alkylphenol. It is an antioxidant and exhibit toxicities mediated by oxidative metabolism to electrophilic quinone methides. It acts as Michael acceptor and its reaction with simple nucleophiles and proteins have been reported.[1] Reaction of 2,6-di-tert-butyl-4-methylphenol with ytterbium(II)-benzophenone dianion complex has been reported.[2] 2,6-Di-tert-butyl-4-methylphenol, a food additive, promotes acute pulmonary toxicity and tumor growth in mice.[3]
Application
2,6-Di-tert-butyl-4-methylphenol may be used in the preparation of an organoaluminum compound, methylaluminum bis(2,6-di-tert-butyl-4-alkylphenoxide).[4]
signalword
Warning
hcodes
pcodes
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1
Storage Class
11 - Combustible Solids
wgk_germany
WGK 2
flash_point_f
260.6 °F - open cup
flash_point_c
127 °C - open cup
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Rene Kupfer et al.
Chemical research in toxicology, 15(8), 1106-1112 (2002-08-20)
Acute pulmonary toxicity and tumor promotion by the food additive 2,6-di-tert-butyl-4-methylphenol (BHT) in mice are well documented. These effects have been attributed to either of two quinone methides, 2,6-di-tert-butyl-4-methylenecyclohexa-2,5-dienone (BHT-QM) formed through direct oxidation of BHT by pulmonary cytochrome P450
Novel crystal structure of ytterbium (II)-benzophenone dianion complex and its reaction with 2, 6-di-tert-butyl-4-methylphenol.
Hou Z, et al.
Journal of the Chemical Society. Chemical Communications, 9, 722-724 (1999)
M A Lewis et al.
Chemical research in toxicology, 9(8), 1368-1374 (1996-12-01)
4-Alkylphenols, such as the antioxidant 2, 6-di-tert-butyl-4-methylphenol (BHT), exhibit toxicities that appear to be mediated by their oxidative metabolism to electrophilic quinone methides. Reactions of these Michael acceptors with simple nucleophiles and proteins have been reported, but little information is
Methylaluminum bis (2, 6-di-tert-butyl-4-alkylphenoxide). A new reagent for obtaining unusual equatorial and anti-Cram selectivity in carbonyl alkylation.
Maruoka K, et al.
Journal of the American Chemical Society, 107(15), 4573-4576 (1985)
A M Vijesh et al.
European journal of medicinal chemistry, 46(11), 5591-5597 (2011-10-05)
In the present study two new series of Hantzsch 1,4-dihydropyridine derivatives (1,4-DHPs) containing substituted pyrazole moiety (4a-f and 5a-f) were synthesized by the reaction of 3-aryl-1H-pyrazole-4-carbaldehydes with 1,3-dicarbonylcompounds (ethylacetoacetate and methylacetoacetate) and ammonium acetate. The newly synthesized compounds were characterized
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Hi Can I use this for HPLC purpose as well. Using it as anti oxidant
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