8-Quinolinol

Name: 8-Quinolinol
Brand: SIAL
Price: 48.15 USD
Availability: InStock

PESTANAL^®, analytical standard

Synonym(s):

8-Hydroxyquinoline, 8-Oxychinolin, Oxine

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250 MG

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About This Item

Empirical Formula (Hill Notation):

C₉H₇NO

CAS Number:

148-24-3

Molecular Weight:

145.16

Beilstein/REAXYS Number:

114512

EC Number:

205-711-1

MDL number:

MFCD00006807

UNSPSC Code:

41116107

PubChem Substance ID:

329755375

NACRES:

NA.24

Key Documents

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grade

analytical standard

Quality Level

100

product line

PESTANAL^®

assay

98-100% (GC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

72.5-74.0 °C

antibiotic activity spectrum

fungi

application(s)

agriculture
cleaning products
cosmetics
environmental
food and beverages
personal care

format

neat

mode of action

DNA synthesis | interferes
enzyme | inhibits

SMILES string

Oc1cccc2cccnc12

InChI

1S/C9H7NO/c11-8-5-1-3-7-4-2-6-10-9(7)8/h1-6,11H

InChI key

MCJGNVYPOGVAJF-UHFFFAOYSA-N

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Analytical Chemistry

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Show Differences

1 of 4

This Item	13-2510	32502	252565
Supelco 36524 8-Quinolinol	Sigma-Aldrich 13-2510 8-Quinolinol	Sigma-Aldrich 32502 8-Quinolinol	Sigma-Aldrich 252565 8-Hydroxyquinoline
application(s) agriculture cleaning products cosmetics environmental food and beverages personal care	application(s) -	application(s) -	application(s) -
technique(s) HPLC: suitable, gas chromatography (GC): suitable	technique(s) -	technique(s) titration: suitable	technique(s) -
format neat	format -	format -	format -
Quality Level 100	Quality Level -	Quality Level 200	Quality Level 200
grade analytical standard	grade JIS special grade	grade ACS reagent, puriss. p.a.	grade ACS reagent
assay 98-100% (GC)	assay ≥99.0%	assay ≥99% (perchloric acid titration)	assay 98.5%

General description

Chemical structure: quinolone

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

PESTANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

GHS06,GHS08,GHS05,GHS09

signalword

Danger

hcodes

H301,H317,H318,H360D,H410

pcodes

P202 - P273 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Repr. 1B - Skin Sens. 1

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number

BCCB5108

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Novel tacrine-8-hydroxyquinoline hybrids as multifunctional agents for the treatment of Alzheimer's disease, with neuroprotective, cholinergic, antioxidant, and copper-complexing properties.

María Isabel Fernández-Bachiller et al.

Journal of medicinal chemistry, 53(13), 4927-4937 (2010-06-16)

Tacrine and PBT2 (an 8-hydroxyquinoline derivative) are well-known drugs that inhibit cholinesterases and decrease beta-amyloid (Abeta) levels by complexation of redox-active metals, respectively. In this work, novel tacrine-8-hydroxyquinoline hybrids have been designed, synthesized, and evaluated as potential multifunctional drugs for

Discovery of potent thermolysin inhibitors using structure based virtual screening and binding assays.

Mahmud Tareq Hassan Khan et al.

Journal of medicinal chemistry, 52(1), 48-61 (2008-12-17)

In the present work, 22 compounds of the U.S. NCI compound library (size 273K) were identified as putative thermolysin binders by structure based virtual screening with the ICM software (ICM-VLS). In vitro competitive binding assays confirmed that 12 were thermolysin

An asymmetric synthesis of 1,2,4-trioxane anticancer agents via desymmetrization of peroxyquinols through a Brønsted acid catalysis cascade.

David M Rubush et al.

Journal of the American Chemical Society, 134(33), 13554-13557 (2012-08-09)

The desymmetrization of p-peroxyquinols using a Brønsted acid-catalyzed acetalization/oxa-Michael cascade was achieved in high yields and selectivities for a variety of aliphatic and aryl aldehydes. Mechanistic studies suggest that the reaction proceeds through a dynamic kinetic resolution of the peroxy

Intra-arterial infusion of human bone marrow-derived mesenchymal stem cells results in transient localization in the brain after cerebral ischemia in rats.

Bhimashankar Mitkari et al.

Experimental neurology, 239, 158-162 (2012-10-13)

Cell therapies from various sources have been under intense research in stroke. Efficient homing of the cells to the injured brain without complications is necessary to realize the therapeutic potential of cell therapy. Intra-arterial (IA) infusion of cells bypasses the

Role of inorganic nitrate and nitrite in driving nitric oxide-cGMP-mediated inhibition of platelet aggregation in vitro and in vivo.

G L Apostoli et al.

Journal of thrombosis and haemostasis : JTH, 12(11), 1880-1889 (2014-08-29)

Nitric oxide (NO) is a critical negative regulator of platelets that is implicated in the pathology of thrombotic diseases. Platelets generate NO, but the presence and functional significance of NO synthase (NOS) in platelets is unclear. Inorganic nitrate/nitrite is increasingly

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