365548

Sigma-Aldrich

Direct Red 80

Dye content 25 %

Synonym(s):
Sirius Red
Empirical Formula (Hill Notation):
C45H26N10Na6O21S6
CAS Number:
Molecular Weight:
1373.07
Colour Index Number:
35780
Beilstein/REAXYS Number:
8185575
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.47

Quality Level

form

powder

composition

Dye content, 25%

application(s)

hematology: suitable
histology: suitable

λmax

528 nm

ε (extinction coefficient)

≥12000 at 277-283 nm in H2O
≥15000 at 223-235 nm in H2O
≥32000 at 524-530 nm in H2O

Featured Industry

Diagnostic Assay Manufacturing

storage temp.

room temp

SMILES string

[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].Oc1c(\N=N\c2ccc(cc2S([O-])(=O)=O)\N=N\c3ccc(cc3)S([O-])(=O)=O)c(cc4cc(NC(=O)Nc5ccc6c(O)c(\N=N\c7ccc(cc7S([O-])(=O)=O)\N=N\c8ccc(cc8)S([O-])(=O)=O)c(cc6c5)S([O-])(=O)=O)ccc14)S([O-])(=O)=O

InChI

1S/C45H32N10O21S6.6Na/c56-43-33-13-5-27(17-23(33)19-39(81(71,72)73)41(43)54-52-35-15-7-29(21-37(35)79(65,66)67)50-48-25-1-9-31(10-2-25)77(59,60)61)46-45(58)47-28-6-14-34-24(18-28)20-40(82(74,75)76)42(44(34)57)55-53-36-16-8-30(22-38(36)80(68,69)70)51-49-26-3-11-32(12-4-26)78(62,63)64;;;;;;/h1-22,56-57H,(H2,46,47,58)(H,59,60,61)(H,62,63,64)(H,65,66,67)(H,68,69,70)(H,71,72,73)(H,74,75,76);;;;;;/q;6*+1/p-6/b50-48+,51-49+,54-52+,55-53+;;;;;;

InChI key

YIQKLZYTHXTDDT-IJPLDVMMSA-H

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General description

Direct Red 80 is a tetra azo dye. It is also known as sirius red F3BA, sirius red F3B etc. It can be used to detect amyloid. It can magnify the usual birefringence of collagen fibers in tissue sections.

Application

Direct Red 80 has been used as an ingredient in the preparation of saturated picric acid for immunohistochemical detection and quantitation of collagen in liver tissues. It has also been used in the staining for collagen.

Packaging

5, 25 g in glass bottle

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
BMP2 regulates Osterix through Msx2 and Runx2 during osteoblast differentiation.
Matsubara T, et al.
The Journal of Biological Chemistry, 283(43), 29119-29125 (2008)
Degradation of a Textile Dye C. I. Direct Red 80 by
Electrochemical Processes
.
Lopes A, et al.
Portugaliae Electrochimica Acta , 279-294 (2004)
Christopher A Miller et al.
Circulation. Cardiovascular imaging, 6(3), 373-383 (2013-04-05)
Extracellular matrix expansion is a key element of ventricular remodeling and a potential therapeutic target. Cardiovascular magnetic resonance (CMR) T1-mapping techniques are increasingly used to evaluate myocardial extracellular volume (ECV); however, the most widely applied methods are without histological validation....
Sabatini M, et al.
Cartilage and Osteoarthritis (2004)
In vivo inhibition of rat stellate cell activation by soluble transforming growth factor beta type II receptor: a potential new therapy for hepatic fibrosis.
George J, et al.
Proceedings of the National Academy of Sciences of the USA, 96(22), 12719-12724 (1999)
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