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390062

Sigma-Aldrich

Thiazole Orange

Dye content ~90 %

Synonym(s):
1-Methyl-4-[(3-methyl-2(3H)-benzothiazolylidene)methyl]quinolinium p-tosylate
Empirical Formula (Hill Notation):
C26H24N2O3S2
CAS Number:
Molecular Weight:
476.61
MDL number:
PubChem Substance ID:
NACRES:
NA.47

form

powder

Quality Level

composition

Dye content, ~90%

mp

270 °C (dec.) (lit.)

λmax

512 nm

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

Cc1ccc(cc1)S([O-])(=O)=O.CN2C(\Sc3ccccc23)=C\c4cc[n+](C)c5ccccc45

InChI

1S/C19H17N2S.C7H8O3S/c1-20-12-11-14(15-7-3-4-8-16(15)20)13-19-21(2)17-9-5-6-10-18(17)22-19;1-6-2-4-7(5-3-6)11(8,9)10/h3-13H,1-2H3;2-5H,1H3,(H,8,9,10)/q+1;/p-1

InChI key

ACOJCCLIDPZYJC-UHFFFAOYSA-M

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General description

Thiazole Orange can be tethered with peptide nucleic acid for the detection of target nucleic acid in homogeneous solution. It is a dye with, both predicted physical characteristics and the biological staining characteristics of a good reticulocyte dye, hence it is considered as a dye for reticulocyte analysis. It has massive fluorescence enhancement and high quantum yield upon binding to nucleic acids, particularly RNA. It is non precipitating and can permeates through live cell membranes.

Application

Thiazole orange has been used for the staining and thereby quantification of reticulocytes.

Packaging

1 g in glass bottle
250 mg in glass bottle

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

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Certificate of Origin

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