394904

Supelco

Pentafluoropropionic anhydride

for GC derivatization, LiChropur, 99%

Synonym(s):
PFPA, Perfluoropropionic anhydride
Linear Formula:
(CF3CF2CO)2O
CAS Number:
Molecular Weight:
310.05
Beilstein/REAXYS Number:
1806446
EC Number:
MDL number:
PubChem Substance ID:

Quality Level

grade

for GC derivatization

assay

99%

quality

LiChropur

reaction suitability

reagent type: derivatization reagent
reaction type: Acylations

application(s)

gas chromatography (GC): suitable

bp

69-70 °C/735 mmHg (lit.)

density

1.571 g/mL at 25 °C (lit.)

SMILES string

FC(F)(F)C(F)(F)C(=O)OC(=O)C(F)(F)C(F)(F)F

InChI

1S/C6F10O3/c7-3(8,5(11,12)13)1(17)19-2(18)4(9,10)6(14,15)16

InChI key

XETRHNFRKCNWAJ-UHFFFAOYSA-N

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Application

Learn more in the Product Information
Derivatization reagent used in a GC-MS analysis of stereoisomer content of synthetic peptides. Also used in a GC-MS detection method for synephrine in dietary supplements.
For the preparation of volatile pentafluoropropionyl derivatives of a wide range of compounds, for example, amines and alcohols, for EC/GC.
Pentafluoropropionic anhydride (PFPA) was used as derivatization reagent for urine samples to determine the presence of codeine, morphine, 6-monoacetylmorphine, ethylmorphine, and dihydrocodeine using GC-MS in selected ion monitoring (SIM) mode. It was also used to derivatize the dry pericardial fluid sample extracts for quantification of cocaine, benzoylecgonine, and cocaethylene in pericardial fluid using GC-MS.

Packaging

10×1, 5, 25, 100 mL in ampule
Clear borosilicate glass, high hydrolytic resistance (Type I)

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Corrosion

Signal Word

Danger

Hazard Statements

Precautionary Statements

hazcat

Skin Corr. 1B

Supp Hazards

EUH014

storage_class_code

8B - Non-combustible, corrosive hazardous materials

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Emilia Marchei et al.
Journal of pharmaceutical and biomedical analysis, 41(4), 1468-1472 (2006-05-16)
A simple and rapid procedure based on gas chromatography-mass spectrometry (GC-MS) is described for determination of synephrine, active principle of Citrus aurantium plant, in solid and liquid dietary supplements. After the addition of 3,4-methylenedioxypropylamphetamine as internal standard (I.S.), a liquid-liquid...
Ralf Pätzold et al.
Chirality, 18(7), 551-557 (2006-05-10)
Synthetic dipeptides comprising mixtures of enantiomers, diastereomers, or sequential isomers were converted into their N-perfluoroacetyl dipeptide esters (perfluoroacetyl: trifluoroacetyl, pentafluoroacetyl, heptafluorobutyryl; ester: methyl, 1-propyl, 2-propyl, 2,2,2-trifluoroethyl) and analyzed by GC-MS on the chiral stationary phases Chirasil-L-Val and Lipodex-E using helium...
Comparison of RapiTest? with Emit? d, au? and GC-MS for the Analysis of Drugs in Urine.
Korte, T., et al.
Journal of Analytical Toxicology, 21, 49-53 (1997)
Y S Oh-Shin et al.
Journal of chromatography. A, 769(2), 285-291 (1997-05-09)
A rapid and simple gas chromatographic method for the simultaneous determination of malathion, parathion, fenitrothion, diazinon and carbaryl in drinking water is presented. A fused-silica SE-54 column was used for the separation of the insecticides and was split into two...
I Jakasa et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 811(2), 177-182 (2004-11-04)
We developed a sensitive method for determination of polyethylene glycols (PEGs) of different molecular weight (MW) in the human stratum corneum (SC) obtained by tape stripping. The analysis is based on derivatization with pentafluoropropionic anhydride (PFPA) and gas chromatography-electron capture...

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