40733

Supelco

trans-2-Tetradecenoyl-L-carnitine

analytical standard

Synonym(s):
C14:1-Carnitine, (2R)-3-Carboxy-N,N,N-trimethyl-2-(2E)-1-oxo-2-tetradecen-1-yloxy-1-propanaminium inner salt, trans-2-Myristenoyl-L-carnitine
Empirical Formula (Hill Notation):
C21H39NO4
Molecular Weight:
369.54
Pricing and availability is not currently available.

grade

analytical standard

assay

≥95.0% (LC/MS)

optical activity

α/D -12±2°, c = 0.1 in methanol

CofA

certificate is enclosed in each package

shelf life

limited shelf life, expiry date on the label

format

neat

storage temp.

−20°C

SMILES string

O-C(C(H)(H)C@(OC(/C(H)=C(H)/C(H)(H)C(H)(H)C(H)(H)C(H)(H)C(H)(H)C(H)(H)C(H)(H)C(H)(H)C(H)(H)C(H)(H)C(H)(H)H)=O)(H)C(H)(H)N+(C(H)(H)H)(C(H)(H)H)C(H)(H)H)=O

General description

trans-2-Tetradecenoyl-L-carnitine, belonging to the class of acylcarnitines, serves as a specific diagnostic metabolite biomarker, which increases in very long-chain acyl CoA dehydrogenase (VLCAD) deficiency, existing as a long-chain β-oxidation defect in newborns.

Application

trans-2-Tetradecenoyl-L-carnitine may be used as an analytical reference standard in the following:
  • Quantification of the analyte in biological samples using high-performance liquid chromatography coupled to tandem mass spectrometry (HPLC/MS/MS).
  • Quantification of the analyte in dried blood spots using chip-based nanoelectrospray source coupled with high resolution mass spectrometry (chip-based nanoESI- HRMS) and targeted liquid chromatography-tandem mass spectrometry (LC/MS/MS).

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Tandem mass spectrometry screening for very long-chain acyl-CoA dehydrogenase deficiency: the value of second-tier enzyme testing
Spiekerkoetter U, et al.
The Journal of Pediatrics, 157(4), 668-673 (2010)
Screening newborns for metabolic disorders based on targeted metabolomics using tandem mass spectrometry
Yoon R-H, et al.
Annals of pediatric endocrinology & metabolism, 20(3), 119-119 (2015)
Quantification of metabolites in dried blood spots by direct infusion high resolution mass spectrometry
Van der Ham M, et al., et al.
Analytica Chimica Acta, 979, 45-50 (2017)
Differences between acylcarnitine profiles in plasma and bloodspots
Diekman FE, et al.
Molecular Genetics and Metabolism, 110(1-2), 116-121 (2013)

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