410225

Sigma-Aldrich

Glycine

ACS reagent, ≥98.5%

Synonym(s):
Aminoacetic acid, Aminoethanoic acid, Glycocoll
Linear Formula:
NH2CH2COOH
CAS Number:
Molecular Weight:
75.07
Beilstein/REAXYS Number:
635782
EC Number:
MDL number:
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.21

Quality Level

grade

ACS reagent

assay

≥98.5%

form

crystals
powder or granules

application(s)

peptide synthesis: suitable

impurities

H2SO4, passes test (darkened)
Hydrolyzable subsances, passes test

ign. residue

≤0.1%

pKa (25 °C)

(1) 2.35, (2) 9.60
2.35

mp

240 °C (dec.) (lit.)

anion traces

chloride (Cl-): ≤0.005%
sulfate (SO42-): ≤0.005%

cation traces

NH4+: ≤0.005%
heavy metals: ≤0.002% (by ICP)

SMILES string

NCC(O)=O

InChI

1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)

InChI key

DHMQDGOQFOQNFH-UHFFFAOYSA-N

Gene Information

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Application

Glycine has been used in whole-cell patch clamp recording to measure inward NMDA (N-methyl-D-aspartate) currents. It has also been used as a model organic system in crystallography to demonstrate a novel acoustic nebulization platform.

Packaging

50, 250 g in poly bottle

Biochem/physiol Actions

Glycine is a non-essential amino acid. Influx of calcium through the cell membrane is mediated by glycine-gated channel. Glycine participates in the synthesis of porphyrins, purine and serine. It also serves as a competitive agonist for glutamate in binding to the NMDA (N-methyl-D-aspartate) receptors. Glycine synthesis might be increased in rapidly proliferating cancer cells, due to increased demand for the amino acid.
Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

A Novel Acoustomicrofluidic Nebulization Technique Yielding New Crystallization Morphologies
Heba Ahmed
Advanced Materials, 30(3) (2018)
Controversial Effects of D-Amino Acid Oxidase Activator (DAOA)/G72 on D-Amino Acid Oxidase (DAO) Activity in Human Neuronal, Astrocyte and Kidney Cell Lines: The N-methyl D-aspartate (NMDA) Receptor Hypofunction Point of View
Vinita Jagannath
Frontiers in Molecular Neuroscience (2017)
Amino acids: metabolism, functions, and nutrition
Guoyao Wu
Amino Acids, 37(1), 1-17 (2009)
Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation
Mohit Jain
Science, 336(6084), 1040-1044 (2012)
Alexander Carvajal-González et al.
Brain : a journal of neurology, 137(Pt 8), 2178-2192 (2014-06-22)
The clinical associations of glycine receptor antibodies have not yet been described fully. We identified prospectively 52 antibody-positive patients and collated their clinical features, investigations and immunotherapy responses. Serum glycine receptor antibody endpoint titres ranged from 1:20 to 1:60 000....

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