Glycine

Name: Glycine
Brand: SIAL

ACS reagent grade, ≥98.5%, powder, crystals or granules

Synonym(s):

Aminoacetic acid, Aminoethanoic acid, Glycocoll

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About This Item

Linear Formula:

NH₂CH₂COOH

CAS Number:

56-40-6

Molecular Weight:

75.07

NACRES:

NA.21

PubChem Substance ID:

24865701

eCl@ss:

32160406

UNSPSC Code:

12352209

EC Number:

200-272-2

MDL number:

MFCD00008131

Beilstein/REAXYS Number:

635782

Key Documents

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Product Name

Glycine, ACS reagent, ≥98.5%

InChI key

DHMQDGOQFOQNFH-UHFFFAOYSA-N

InChI

1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)

SMILES string

NCC(O)=O

grade

ACS reagent

assay

≥98.5%

form

powder, crystals or granules

impurities

H₂SO₄, passes test (darkened)
Hydrolyzable subsances, passes test

ign. residue

≤0.1%

color

white

pKa (25 °C)

(1) 2.35, (2) 9.60
2.35

mp

240 °C (dec.) (lit.)

anion traces

chloride (Cl^-): ≤0.005%
sulfate (SO₄^2-): ≤0.005%

cation traces

NH₄⁺: ≤0.005%
heavy metals: ≤0.002% (by ICP)

application(s)

peptide synthesis

functional group

amine
carboxylic acid

Quality Level

200

Gene Information

rat ... Grin2a(24409)

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Chemistry & Biochemicals

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Show Differences

1 of 4

This Item	1.03669	1.00590	PHR1111
Sigma-Aldrich 410225 Glycine	SAFC 1.03669 Glycine	SAFC 1.00590 Glycine	Supelco PHR1111 Glycine
form powder, crystals or granules	form granular	form crystalline, solid	form -
grade ACS reagent	grade -	grade -	grade certified reference material, pharmaceutical secondary standard
assay ≥98.5%	assay 99.0-101.0% (calculated on dried substance, perchloric acid titration)	assay 98.5-101.0% (calculated on dried substance, perchloric acid titration)	assay -
functional group amine, carboxylic acid	functional group -	functional group -	functional group -
cation traces NH₄⁺: ≤0.005%, heavy metals: ≤0.002% (by ICP)	cation traces -	cation traces -	cation traces -
impurities H₂SO₄, passes test (darkened), Hydrolyzable subsances, passes test	impurities -	impurities -	impurities -

Application

Glycine has been used in whole-cell patch clamp recording to measure inward NMDA (N-methyl-D-aspartate) currents.[1] It has also been used as a model organic system in crystallography to demonstrate a novel acoustic nebulization platform.[2]

Biochem/physiol Actions

Glycine is a non-essential amino acid.[3] Influx of calcium through the cell membrane is mediated by glycine-gated channel. Glycine participates in the synthesis of porphyrins, purine and serine. It also serves as a competitive agonist for glutamate in binding to the NMDA (N-methyl-D-aspartate) receptors.[4] Glycine synthesis might be increased in rapidly proliferating cancer cells, due to increased demand for the amino acid.[3]

Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

General description

Glycine is the simplest amino acid building block.

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number

0000520867

0000476860

0000473224

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Controversial Effects of D-Amino Acid Oxidase Activator (DAOA)/G72 on D-Amino Acid Oxidase (DAO) Activity in Human Neuronal, Astrocyte and Kidney Cell Lines: The N-methyl D-aspartate (NMDA) Receptor Hypofunction Point of View

Vinita Jagannath

Frontiers in Molecular Neuroscience (2017)

A Novel Acoustomicrofluidic Nebulization Technique Yielding New Crystallization Morphologies

Heba Ahmed

Advanced Materials, 30(3) (2018)

Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation

Mohit Jain

Science, 336(6084), 1040-1044 (2012)

Amino acids: metabolism, functions, and nutrition

Guoyao Wu

Amino Acids, 37(1), 1-17 (2009)

Glycine receptor antibodies in PERM and related syndromes: characteristics, clinical features and outcomes.

Alexander Carvajal-González et al.

Brain : a journal of neurology, 137(Pt 8), 2178-2192 (2014-06-22)

The clinical associations of glycine receptor antibodies have not yet been described fully. We identified prospectively 52 antibody-positive patients and collated their clinical features, investigations and immunotherapy responses. Serum glycine receptor antibody endpoint titres ranged from 1:20 to 1:60 000.

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Questions

1–2 of 2 Questions

Anonymous

6 months ago

How can I determine the shelf life / expiration / retest date of this product?

1 answer
1. Technical Support
  
  6 months ago
  
  If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
  For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
  For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
  For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf
  
  Helpful?
Anonymous

a year ago

How is shipping temperature determined? And how is it related to the product storage temperature?

1 answer
1. Technical Support
  
  a year ago
  
  Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
  
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