45554

Supelco

Maneb

PESTANAL®, analytical standard

Synonym(s):
Manganese ethylenebis(dithiocarbamate)
Linear Formula:
[C4H6MnN2S4]n
CAS Number:
Beilstein/REAXYS Number:
3747585
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

Quality Level

grade

analytical standard

product line

PESTANAL®

form

neat

shelf life

limited shelf life, expiry date on the label

mol wt

Mw 265.30 (as monomer)

application(s)

HPLC: suitable
gas chromatography (GC): suitable

Featured Industry

Agriculture
Environmental

format

neat

storage temp.

2-8°C

SMILES string

S=C1NCCNC(=S)S[Mn]S1

InChI

1S/C4H8N2S4.Mn/c7-3(8)5-1-2-6-4(9)10;/h1-2H2,(H2,5,7,8)(H2,6,9,10);/q;+2/p-2

InChI key

YKSNLCVSTHTHJA-UHFFFAOYSA-L

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Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

PESTANAL is a registered trademark of Sigma-Aldrich International GmbH

Signal Word

Warning

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

UN 2210 4.3(4.2) / PGIII

WGK Germany

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Garima Srivastava et al.
Free radical biology & medicine, 52(8), 1294-1306 (2012-02-16)
A strong association between polymorphisms of the cytochrome P450 (CYP/Cyp) 2D6 gene and risk to Parkinson's disease (PD) is well established. The present study investigated the neuroprotective potential of Cyp2d22, a mouse ortholog of human CYP2D6, in maneb- and paraquat-induced...
Colin C Anderson et al.
Toxicological sciences : an official journal of the Society of Toxicology, 165(1), 61-73 (2018-05-17)
The pesticides paraquat (PQ) and maneb (MB) have been described as environmental risk factors for Parkinson's disease (PD), with mechanisms associated with mitochondrial dysfunction and reactive oxygen species generation. A combined exposure of PQ and MB in murine models and...
Paula Desplats et al.
Molecular neurodegeneration, 7, 49-49 (2012-09-29)
Parkinson's disease (PD) is a multifactorial disease where environmental factors act on genetically predisposed individuals. Although only 5% of PD manifestations are associated with specific mutations, majority of PD cases are of idiopathic origin, where environment plays a prominent role....
Sharawan Yadav et al.
Neurochemical research, 37(4), 875-884 (2011-12-28)
Maneb and paraquat are known to induce Parkinson's disease (PD) phenotype, however, caffeine offers neuroprotection. Nitric oxide (NO) acts an important mediator in PD phenotype and tyrosine kinase (TK), nuclear factor kappa B (NF-kB), p38 mitogen activated protein kinase (p38...
Seema Gollamudi et al.
PloS one, 7(5), e36191-e36191 (2012-05-09)
Parkinson's disease (PD) is a neurodegenerative disease in which the etiology of 90 percent of the patients is unknown. Pesticide exposure is a major risk factor for PD, and paraquat (PQ), pyridaben (PY) and maneb (MN) are amongst the most...

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