Novobiocin sodium salt

Name: Novobiocin sodium salt
Brand: SIAL
Price: 108 USD

VETRANAL^®, analytical standard

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250 MG

$108.00

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About This Item

Empirical Formula (Hill Notation):

C₃₁H₃₅N₂NaO₁₁

CAS Number:

1476-53-5

Molecular Weight:

634.61

PubChem Substance ID:

24870266

UNSPSC Code:

41116107

MDL number:

MFCD07636891

NACRES:

NA.24

EC Number:

216-023-6

Beilstein/REAXYS Number:

3892910

Key Documents

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Product Name

Novobiocin sodium salt, VETRANAL^®, analytical standard

InChI

1S/C31H35N2O11.Na/c1-14(2)7-8-16-13-17(9-11-19(16)34)27(37)33-21-22(35)18-10-12-20(15(3)24(18)42-28(21)38)41-29-23(36)25(43-30(32)39)26(40-6)31(4,5)44-29;/h7,9-13,23,25-26,29,34,36H,8H2,1-6H3,(H2,32,39)(H,33,37);/q-1;+1

InChI key

AXOUUAINTJNFRS-UHFFFAOYSA-N

SMILES string

[Na+].CO[C@@H]1[C@@H](OC(N)=O)[C@@H](O)[C@H](Oc2ccc3C([O-])=C(NC(=O)c4ccc(O)c(C\C=C(\C)C)c4)C(=O)Oc3c2C)OC1(C)C

grade

analytical standard

product line

VETRANAL^®

assay

97.9% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

antibiotic activity spectrum

Gram-positive bacteria

application(s)

clinical testing

format

neat

mode of action

DNA synthesis | interferes
enzyme | inhibits

storage temp.

2-8°C

Quality Level

100

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Show Differences

1 of 4

This Item	N1628	N6160	491207
Supelco 46531 Novobiocin sodium salt	Sigma-Aldrich N1628 Novobiocin sodium salt	Sigma-Aldrich N6160 Novobiocin sodium	Sigma-Aldrich 491207 Novobiocin, Sodium Salt
application(s) clinical testing	application(s) -	application(s) pharmaceutical (small molecule)	application(s) -
technique(s) HPLC: suitable, gas chromatography (GC): suitable	technique(s) -	technique(s) -	technique(s) -
format neat	format -	format -	format -
Quality Level 100	Quality Level 200	Quality Level 200	Quality Level -
grade analytical standard	grade -	grade -	grade -
assay 97.9% (HPLC)	assay ≥90% (HPLC)	assay -	assay ≥90% (HPLC)

Application

For the production of positively supercoiled plasmid DNA. Inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase. Inhibitor of retrovirus RNA-dependent DNA-polymerase.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Mode of Action: Inhibits DNA synthesis by inhibiting the enzyme Topoisomerase II.
Antimicrobial spectrum: Gram-positive bacterial.

General description

Chemical structure: coumarin-glycoside

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

GHS07

signalword

Warning

hcodes

H302,H317,H319

pcodes

P261 - P264 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number

BCCK2243

BCCB6920

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Rhomboids of Mycobacteria: characterization using an aarA mutant of Providencia stuartii and gene deletion in Mycobacterium smegmatis.

David Patrick Kateete et al.

PloS one, 7(9), e45741-e45741 (2012-10-03)

Rhomboids are ubiquitous proteins with unknown roles in mycobacteria. However, bioinformatics suggested putative roles in DNA replication pathways and metabolite transport. Here, mycobacterial rhomboid-encoding genes were characterized; first, using the Providencia stuartii null-rhomboid mutant and then deleted from Mycobacterium smegmatis

A forward chemical screen identifies antibiotic adjuvants in Escherichia coli.

Patricia L Taylor et al.

ACS chemical biology, 7(9), 1547-1555 (2012-06-16)

Multi-drug-resistant infections caused by Gram-negative pathogens are rapidly increasing, highlighting the need for new chemotherapies. Unlike Gram-positive bacteria, where many different chemical classes of antibiotics show efficacy, Gram-negatives are intrinsically insensitive to many antimicrobials including the macrolides, rifamycins, and aminocoumarins

Thai ethnomedicinal plants as resistant modifying agents for combating Acinetobacter baumannii infections.

Pinanong Na Phatthalung et al.

BMC complementary and alternative medicine, 12, 56-56 (2012-04-28)

Acinetobacter baumannii is well-recognized as an important nosocomial pathogen, however, due to their intrinsic resistance to several antibiotics, treatment options are limited. Synergistic effects between antibiotics and medicinal plants, particularly their active components, have intensively been studied as alternative approaches.

Potent antitrypanosomal activities of heat shock protein 90 inhibitors in vitro and in vivo.

Kirsten J Meyer et al.

The Journal of infectious diseases, 208(3), 489-499 (2013-05-01)

African sleeping sickness, caused by the protozoan parasite Trypanosoma brucei, is universally fatal if untreated, and current drugs are limited by severe toxicities and difficult administration. New antitrypanosomals are greatly needed. Heat shock protein 90 (Hsp90) is a conserved and

Pharmacologically tunable polyethylene-glycol-based cell growth substrate.

Raphael J Gübeli et al.

Acta biomaterialia, 9(9), 8272-8278 (2013-05-21)

Biohybrid materials combining synthetic polymers with biological components are highly suited for tissue engineering in order to emulate the behavior of natural materials such as the extracellular matrix (ECM). In order to allow for an optimal cell-material interplay, the physical

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