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48912-U

Sigma-Aldrich

ProClin™ 300

pkg of 50 mL

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NACRES:
NA.21

contains

Alkyl Carboxylate

Quality Level

300

composition

CMIT/MIT, 3%

packaging

pkg of 50 mL

matrix

Modified glycol

operating pH range

2.5-8.5

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This Item
49376-U46878-U48171-U
ProClin™ 300 pkg of 50 mL

Sigma-Aldrich

48912-U

ProClin™ 300

ProClin™ 150 pkg of 50 mL

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49376-U

ProClin™ 150

ProClin™ 950 pkg of 50 mL

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46878-U

ProClin™ 950

ProClin™ 200 pkg of 50 mL

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ProClin™ 200

composition

CMIT/MIT, 3%

composition

CMIT/MIT, 1.5%

composition

MIT, 9.5%

composition

CMIT/MIT, 1.5%

packaging

pkg of 50 mL

packaging

pkg of 50 mL

packaging

pkg of 50 mL

packaging

pkg of 50 mL

matrix

Modified glycol

matrix

Water

matrix

Water

matrix

Water

operating pH range

2.5-8.5

operating pH range

2.5-8.5

operating pH range

2-12

operating pH range

2.5-8.5

Quality Level

300

Quality Level

300

Quality Level

300

Quality Level

300

General description

ProClin™ preservatives are water-soluble preparations of biocides that are generally used to increase the shelf life of reagents. ProClin™ 300 comprises of 3% of 5-chloro-2-methyl-4-isothiazolin-3-one (CMIT) and 2-methyl-4-isothiazloin-3-one (MIT) in a salt-free proprietary glycol containing an alkly carboxylate stabilizer. It has a recommended working pH range as 2.5 - 8.5.

Application

For use in biological diagnostic assays and IVDs only
ProClin biocides are immediately microstatic upon contact with microbial organisms as a result of their ability to quickly penetrate cell membranes and inhibit specific enzymes crucial to cellular respiration. Multiple specific sites of ProClin toxicity prevent microorganisms from developing high levels of resistance, making ProClin highly efficient even over extended storage periods of your IVD components.
ProClin™ 300 is suitable for preparation of different buffers like ELISA buffer, sample and substrate dilution buffers for Single-Molecule Arrays (Simoa assay) and Immunoenzymatic assay. Additionally, Proclin™ may be used in preparing storage buffer to store beads coupled with coronavirus nucleocapsid protein for the serological multiplex assay.

Biochem/physiol Actions

ProClin™ products contain active substances like CMIT and MIT which inhibit the Krebs cycle at four different check points, the enzymes pyruvate dehydrogenase, α-ketoglutarate dehydrogenase, succinate dehydrogenase, and NADH dehydrogenase. The inhibition of Krebs cycle leads to effective broad-spectrum biocidal activity against bacteria, fungi, and yeast.

Legal Information

ProClin is a trademark of The Dow Chemical Company or an affiliated company of Dow

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1

Storage Class Code

8A - Combustible, corrosive hazardous materials

WGK

WGK 3

Flash Point(F)

244.4 °F - closed cup

Flash Point(C)

118 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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25G
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Single Molecule Arrays for ultra-sensitive detection of rat cytokines in serum
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