Skip to Content
MilliporeSigma
All Photos(4)

Key Documents

571024

Sigma-Aldrich

Chlorosulfonic acid

99%

Synonym(s):

Sulfuric chlorohydrin

Sign Into View Organizational & Contract Pricing


About This Item

Linear Formula:
ClSO3H
CAS Number:
Molecular Weight:
116.52
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.21

vapor density

4 (vs air)

Quality Level

vapor pressure

1 mmHg ( 25 °C)
3.3 mmHg ( 37.7 °C)

assay

99%

expl. lim.

37.7 %

refractive index

n20/D 1.433 (lit.)

bp

151-152 °C/755 mmHg (lit.)

solubility

acetic acid: soluble(lit.)
chloroform: soluble(lit.)
dichloromethane: soluble(lit.)

density

1.753 g/mL at 25 °C (lit.)

SMILES string

OS(Cl)(=O)=O

InChI

1S/ClHO3S/c1-5(2,3)4/h(H,2,3,4)

InChI key

XTHPWXDJESJLNJ-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

General description

Chlorosulfonic acid is a strong acid that is synthesized on an industrial scale by reacting sulfur trioxide and dry hydrogen chloride gas in an equimolar ratio. It can act as a sulfonating, dehydrating, oxidizing and chlorinating agent. It is reported to be a better electrophilic olefin cyclization agent in comparison to other sulfonic acids. Its infrared spectra in the solid, liquid and gaseous state have been recorded in the region 4000-400cm-1.

Application

Chlorosulfonic acid may be used in the following processes:
  • Synthesis of di-n-butyl ammonium chlorosulfonate, a secondary amine ionic liquid.
  • To prepare sulfonated polyethersulfone (SPES) with enhanced hydrophilic property.
  • To attach sulfate group to silk fibroin for improving its anticoagulant ability.
  • As a catalyst to prepare substituted coumarin, via von Pechmann condensation between phenol and β-ketoester.
  • As a substitute to acid catalyst in Biginelli reaction to prepare 3,4dihydropyrimidines.

pictograms

Skull and crossbonesCorrosion

signalword

Danger

Hazard Classifications

Acute Tox. 1 Inhalation - Eye Dam. 1 - Skin Corr. 1A - STOT SE 3

target_organs

Respiratory system

supp_hazards

Storage Class

6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter


Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Chlorosulfonic acid-catalysed one-pot synthesis of coumarin.
Kotharkar SA, et al.
Mendeleev Communications, 16(4), 241-242 (2006)
Chlorosulfonic acid catalyzed highly efficient solvent-free synthesis of 3,4-Dihydropyrimidin-2(1H)-one and thiones.
Kotharkar SA, et al.
Ukrainica Bioorganica Acta, 2, 17-21 (2006)
Polyethersulfone sulfonated by chlorosulfonic acid and its membrane characteristics.
Guan R, et al.
European Polymer Journal, 41(7), 1554-1560 (2005)
Di-n-butyl ammonium chlorosulfonate as a highly efficient and recyclable ionic liquid for the synthesis of N-containing bisphosphonates.
Reddy MV, et al.
Catalysis Communications, 61, 102-106 (2015)
Chlorosulfonic acid as a convenient electrophilic olefin cyclization agent.
Linares-Palomino PJ, et al.
Tetrahedron Letters, 44(35), 6651-6655 (2003)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service