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574732

Sigma-Aldrich

Acetonitrile solution

suitable for HPLC, contains 0.1 % (v/v) trifluoroacetic acid

Synonym(s):

ACN, Cyanomethane, Ethyl nitrile, Methyl cyanide

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About This Item

Linear Formula:
CH3CN
CAS Number:
Molecular Weight:
41.05
Beilstein/REAXYS Number:
4124158
EC Number:
MDL number:
UNSPSC Code:
12190000
PubChem Substance ID:
NACRES:
NA.03

product name

Acetonitrile solution, contains 0.1 % (v/v) trifluoroacetic acid, suitable for HPLC

vapor density

1.41 (vs air)

Quality Level

vapor pressure

72.8 mmHg

form

liquid

contains

0.1 % (v/v) trifluoroacetic acid

expl. lim.

8 %

technique(s)

HPLC: suitable

bp

81-82 °C

mp

-48 °C

density

0.782 g/mL at 25 °C

application(s)

food and beverages

format

mixture

SMILES string

CC#N

InChI

1S/C2H3N/c1-2-3/h1H3

InChI key

WEVYAHXRMPXWCK-UHFFFAOYSA-N

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General description

The product is an acetonitrile solution containing 0.1%v/v trifluoroacetic acid. This pre-blended mobile phase solvent is of high purity that reduces time-consuming preparation and prevents instrument downtime because of impure mobile phases. Trifluoroacetic acid/acetonitrile mobile phase system is generally employed for peptide separation. Acetonitrile (MeCN), an organic solvent has low viscosity, high elution strength and is UV transparent at low wavelength. Trifluoroacetic acid (TFA) is commonly used as a mobile phase additive. It is a volatile acid that forms hydrophobic negatively charged trifluoroacetate ion.

Application


  • Preparation and characterization of stationary phase gradients on C8 liquid chromatography columns.: This study explores the development and analysis of stationary phase gradients on C8 columns, crucial for optimizing chromatographic separations in analytical chemistry (Cecil et al., 2024).

  • Metal-cation-induced shifts in thiolate redox and reduced sulfur speciation.: Investigates the impact of metal cations on the redox behavior of thiolates, a key area in understanding redox processes in various chemical systems (Seo et al., 2024).

  • A Phosphine-Oxide Cobalt(II) Complex and Its Catalytic Activity Studies toward Alcohol Dehydrogenation Triggered Direct Synthesis of Imines and Quinolines.: Describes the catalytic role of a cobalt(II) phosphine-oxide complex in synthesizing imines and quinolines from alcohols, a significant contribution to synthetic organic chemistry (Khatua et al., 2024).

  • [Simultaneous determination of 31 banned veterinary drugs during egg-laying period in poultry eggs by ultra performance liquid chromatography-tandem mass spectrometry].: This Chinese study presents a method for detecting multiple veterinary drugs in eggs, highlighting advancements in food safety and analytical methodologies (Zhu et al., 2024).

  • Probing Isolated Water Molecules in Aqueous Acetonitrile Solutions Using Oxygen K-Edge X-ray Absorption Spectroscopy.: Focuses on the molecular dynamics of water in acetonitrile solutions, providing insights that are crucial for understanding solvent effects in various chemical environments (Nagasaka, 2024).

Preparation Note

Product filtered through a 0.2 μm filter

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pictograms

FlameExclamation mark

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Storage Class

3 - Flammable liquids

wgk_germany

WGK 2

flash_point_f

42.8 °F - closed cup

flash_point_c

6 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter


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Optimum concentration of trifluoroacetic acid for reversed-phase liquid chromatography of peptides revisited.
Chen Y, et al.
Journal of Chromatography A, 1043(1), 9-18 (2004)
Acetonitrile, the polarity chameleon.
Zarzycki PK, et al.
Analytical and Bioanalytical Chemistry, 397(3), 905-908 (2010)
Eagleson M.
Concise Encyclopedia Chemistry, 6-6 (1994)
Maria de la Paz Celorio-Mancera et al.
Insect biochemistry and molecular biology, 61, 34-45 (2015-05-03)
More than half of the proteome from mandibular glands in caterpillars is represented by chemosensory proteins. Based on sequence similarity, these proteins are putative transporters of ligands to gustatory receptors in sensory organs of insects. We sought to determine whether
Divya Subramonian et al.
Journal of proteome research, 13(9), 3905-3918 (2014-07-30)
SUMOylation is an essential posttranslational modification and regulates many cellular processes. Dysregulation of SUMOylation plays a critical role in metastasis, yet how its perturbation affects this lethal process of cancer is not well understood. We found that SUMO-2/3 modification is

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