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58360

Sigma-Aldrich

Isobutyric acid

puriss. p.a., ≥99.5%

Synonym(s):
2-Methylpropionic acid
Linear Formula:
(CH3)2CHCO2H
CAS Number:
Molecular Weight:
88.11
Beilstein:
635770
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22

Quality Level

vapor density

3.04 (vs air)

vapor pressure

1.5 mmHg ( 20 °C)

grade

puriss. p.a.

assay

≥99.5% (GC)
≥99.5%

autoignition temp.

824 °F

expl. lim.

10 %

impurities

≤0.2% water

refractive index

n20/D 1.393 (lit.)
n20/D 1.393

bp

153-154 °C (lit.)

mp

−47 °C (lit.)

density

0.95 g/mL at 25 °C (lit.)

cation traces

Al: ≤0.5 mg/kg
Ba: ≤0.1 mg/kg
Bi: ≤0.1 mg/kg
Ca: ≤0.5 mg/kg
Cd: ≤0.05 mg/kg
Co: ≤0.02 mg/kg
Cr: ≤0.02 mg/kg
Cu: ≤0.02 mg/kg
Fe: ≤0.1 mg/kg
K: ≤0.5 mg/kg
Li: ≤0.1 mg/kg
Mg: ≤0.1 mg/kg
Mn: ≤0.02 mg/kg
Mo: ≤0.1 mg/kg
Na: ≤2 mg/kg
Ni: ≤0.02 mg/kg
Pb: ≤0.1 mg/kg
Sr: ≤0.1 mg/kg
Zn: ≤0.1 mg/kg

SMILES string

CC(C)C(O)=O

InChI

1S/C4H8O2/c1-3(2)4(5)6/h3H,1-2H3,(H,5,6)

InChI key

KQNPFQTWMSNSAP-UHFFFAOYSA-N

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General description

Isobutyric acid can be prepared via the carbonylation of propylene.

Application

Isobutyric acid may be used to synthesize methacrylic acid via oxidative dehydrogenation in the presence of a suitable heteropolyacid as catalyst.

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1B

Storage Class Code

3 - Flammable liquids

WGK Germany

WGK 1

Flash Point(F)

131.0 °F - closed cup

Flash Point(C)

55 °C - closed cup

Certificate of Analysis

Certificate of Origin

"Acidic cesium salts of molybdovanadophosphoric acids as efficient catalysts for oxidative dehydrogenation of isobutyric acid"
Lee YK, et al.
Catalysis Today, 33(1-3), 183-189 (1997)
E M Faed et al.
Clinical and experimental pharmacology & physiology, 5(2), 195-198 (1978-03-01)
1. Two main conjugates of CPIB (2-[chlorophenoxy]-2-methylpropionic acid) are present in the urine of subjects taking clofibrate. The metabolites can be separated by thin-layer chromatography (TLC). 2. Both conjugates are hydrolysed by dilute alkali, but only one is hydrolysed by...
A Vyalikh et al.
Physical chemistry chemical physics : PCCP, 9(18), 2249-2257 (2007-05-10)
Solid state deuterium NMR has been used to study the molecular motion of d(6)-isobutyric acid (d(6)-iBA) in the pure (unconfined) state and confined in the cylindrical pores of two periodic mesoporous silica materials (MCM-41, pore size 3.3 nm and SBA-15...
Nicoletta Beffagna et al.
Journal of experimental botany, 58(15-16), 4183-4194 (2007-11-28)
In Arabidopsis thaliana cells, fusicoccin (FC) treatment induced an early and marked increase in the extracellular H(2)O(2) level. It also increased the huge hypo-osmotic stress-induced oxidative wave and, in addition, prevented the H(2)O(2) peak drop. These effects were apparently not...
Kimberlee S Mix et al.
Molecular pharmacology, 65(2), 309-318 (2004-01-27)
Matrix metalloproteinases (MMPs) degrade extracellular matrix components, and overexpression of these enzymes contributes to tissue destruction in arthritis. Of particular importance are the collagenases, MMP-1 and MMP-13, which have high activity against the interstitial collagens in cartilage. In this study...

Articles

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