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59924

Sigma-Aldrich

Polysorbate 80

tested according to Ph. Eur.

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Synonym(s):
TWEEN® 80, Polysorbatum 80, POE (20) sorbitan monooleate, Polyethylene glycol sorbitan monooleate, Polyoxyethylenesorbitan monooleate, Polysorbate 80
CAS Number:
MDL number:
NACRES:
NA.21

agency

USP/NF
tested according to Ph. Eur.

Quality Level

vapor pressure

<1 mmHg ( 20 °C)

description

non-ionic

form

liquid

mol wt

average mol wt 79,000

aggregation number

60

refractive index

n20/D 1.472 (lit.)

CMC

0.012

transition temp

cloud point 65 °C

density

1.064 g/mL at 25 °C (lit.)

HLB

15

application(s)

pharmaceutical (small molecule)

SMILES string

CCCCCCCC/C=C/CCCCCCCC(=O)OCCOCC(C1C(CC(O1)OCCO)OCCO)OCCO

InChI

1S/C32H60O10/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-30(36)40-25-24-37-27-29(39-22-19-34)32-28(38-21-18-33)26-31(42-32)41-23-20-35/h9-10,28-29,31-35H,2-8,11-27H2,1H3/b10-9+

InChI key

RGPBUVUVZKQNHD-MDZDMXLPSA-N

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1 of 4

This Item
W291706P8074PHR3790
vibrant-m

59924

Polysorbate 80

-
vibrant-m

W291706

Polysorbate 80

-
vibrant-m

P8074

TWEEN® 80

Premium Grade
vibrant-m

PHR3790

Polysorbate 80

-
aggregation number

60

aggregation number

-

aggregation number

60

aggregation number

-

application(s)

pharmaceutical (small molecule)

application(s)

flavors and fragrances

application(s)

-

application(s)

pharmaceutical

Quality Level

200

Quality Level

400

Quality Level

200

Quality Level

300

CMC

0.012

CMC

-

CMC

0.012 mM (20-25°C)

CMC

-

description

non-ionic

description

-

description

non-ionic

description

-

General description

Polysorbate 80 is a surfactant. Polysorbates are a combination of oleic esters of sorbitol and sorbitanes with polyethylene glycol chains.

Application

Polysorbate 80 has been used in drug (rapamycin) treatment and to study the effect of rapamycin on osteolysis and tumor growth. It has also been used in the preparation of spray-dried emulsions and to study antibacterial efficacy.

Biochem/physiol Actions

Polysorbates is used as emulsifiers, dissolving agents and stabilizer for essential oils, topical application and medical infusions including intravenous, subcutaneous or intramuscular administration.

Legal Information

TWEEN is a registered trademark of Croda International PLC

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves


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Alvarez Nunez FA and Yalkowsky SH
International Journal of Pharmaceutics, 200(2), 217-222 (2000)
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Coors EA, et al.
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Characterizing protein aggregates in the presence of silicone oil is a long standing challenge for the pharmaceutical industry. Silicone oil is often used as a lubricant in devices that deliver and store therapeutic protein products and has been linked to
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