61313

L-α-Hydroxyglutaric acid disodium salt

analytical standard

• Synonym(s): (S)-2-Hydroxypentanedioic acid disodium salt, Disodium (S)-2-hydroxyglutarate
• Linear Formula: C₅H₆O₅Na₂
• CAS Number: 63512-50-5
• Molecular Weight: 192.08
• Beilstein: 5318042
• MDL number: MFCD00021700

Properties

• grade: analytical standard
• Assay: ≥98.0% (GC)
• optical activity: [α]/D -8.5±1.5°, c = 1 in 0.1 M NaOH
• shelf life: limited shelf life, expiry date on the label
• application(s): clinical testing
• format: neat
• storage temp.: 2-8°C
• SMILES string: [O-]C(CC[C@@H](C([O-])=O)O)=O.[Na+].[Na+]
• InChI: 1S/C5H8O5.2Na/c6-3(5(9)10)1-2-4(7)8;;/h3,6H,1-2H2,(H,7,8)(H,9,10);;/q;2*+1/p-2/t3-;;/m0../s1
• InChI key: DZHFTEDSQFPDPP-QTNFYWBSSA-L

Description

Biochem/physiol Actions

L-alpha-Hydroxyglutaric acid accumulates as a result of a rare defect in L-2-HG dehydogenase, leading to the metabolic disorder L-2-hydroxyglutaric aciduria (L-2HGA). L-2HGA is associated with neuronal defects, leukodystrophy and linked to an increased risk of brain tumors.

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point(C): Not applicable