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61347

Supelco

10,11-Dihydro-10-hydroxycarbamazepine

analytical standard

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Synonym(s):
10,11-Dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide, Licarbazepine
Empirical Formula (Hill Notation):
C15H14N2O2
CAS Number:
29331-92-8
Molecular Weight:
254.28
Beilstein:
1540211
MDL number:
MFCD00871817
PubChem Substance ID:
329759441
NACRES:
NA.24

grade

analytical standard

Quality Level

100

Assay

≥99% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

InChI

1S/C15H14N2O2/c16-15(19)17-12-7-3-1-5-10(12)9-14(18)11-6-2-4-8-13(11)17/h1-8,14,18H,9H2,(H2,16,19)

InChI key

BMPDWHIDQYTSHX-UHFFFAOYSA-N

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This Item
D-0911953293203
10,11-Dihydro-10-hydroxycarbamazepine analytical standard

Supelco

61347

10,11-Dihydro-10-hydroxycarbamazepine

10,11-Dihydro-10-Hydroxycarbamazepine solution 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

Supelco

D-091

10,11-Dihydro-10-Hydroxycarbamazepine solution

Oxcarbazepine analytical standard

Supelco

19532

Oxcarbazepine

Carbamazepine 10,11-epoxide analytical standard

Supelco

93203

Carbamazepine 10,11-epoxide

assay

≥99% (HPLC)

assay

-

assay

≥97.5% (HPLC)

assay

≥99.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

shelf life

-

shelf life

limited shelf life, expiry date on the label

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

application(s)

clinical testing

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

format

single component solution

format

neat

format

neat

General description

10,11-Dihydro-10-hydroxycarbamazepine is a 10-hydroxy derivative and an active metabolite of oxcarbazepine.
10,11-Dihydro-10-hydroxycarbamazepine is an active metabolite of the antiepileptic drug, oxcarbazepine.

Application

10,11-Dihydro-10-hydroxycarbamazepine may be used as a reference standard in the determination of 10,11-dihydro-10-hydroxycarbamazepine in biological samples using liquid chromatography, liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) and high performance liquid chromatography coupled with ultraviolet detector (HPLC-UV).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictograms

Environment
GHS09

Hazard Statements

H411

Precautionary Statements

P273

Hazard Classifications

Aquatic Chronic 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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MMYOMAG-74K-13

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Carbamazepine 10,11-epoxide analytical standard

Supelco

C4206

Carbamazepine 10,11-epoxide

Oxcarbazepine Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1635

Oxcarbazepine

Oxcarbazepine European Pharmacopoeia (EP) Reference Standard

Y0001576

Oxcarbazepine

BIA 2-093 ≥98% (HPLC), solid

Sigma-Aldrich

B5435

BIA 2-093

Oxcarbazepine ≥98% (HPLC), solid

Sigma-Aldrich

O3764

Oxcarbazepine

Stiripentol ≥98% (HPLC)

Sigma-Aldrich

S6826

Stiripentol

Topiramate ≥98% (HPLC), solid

Sigma-Aldrich

T0575

Topiramate

USP

USP

1667235

Racemic Tiagabine Hydrochloride Mixture

Liquid chromatographic analysis of oxcarbazepine and its metabolites in plasma and saliva after a novel microextraction by packed sorbent procedure.
Saracino M A, et al.
Analytica Chimica Acta, 661(2), 222-228 (2010)
Simultaneous quantitative analysis of oxcarbazepine and 10, 11-dihydro-10-hydroxycarbamazepine in human plasma by liquid chromatography-electrospray tandem mass spectrometry.
Maia SdBM, et al.
Journal of Pharmaceutical and Biomedical Analysis, 45(2), 304-311 (2007)
Anne-Catherine Servais et al.
Journal of chromatography. A, 1467, 306-311 (2016-07-22)
A LC method using a chiral stationary phase (CSP) with cellulose tris(3-chloro-4-methylphenylcarbamate) as chiral selector in polar organic mode (POM) was developed for the separation of the biopharmaceutic classification system (BCS) class II chiral prodrug eslicarbazepine acetate (ESL) and its
Johannes Pohl et al.
Environmental science & technology, 54(5), 2913-2921 (2020-01-29)
Carbamazepine (CBZ) is an anticonvulsant medication with highly persistent properties in the aquatic environment, where it has the potential to affect nontarget biota. Because CBZ and many other pharmaceuticals are not readily removed in conventional sewage treatment plants (STP), additional
Shengyang Zhou et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1141, 122036-122036 (2020-02-29)
In this study, haptens were designed to produce highly sensitive and specific monoclonal antibodies (mAb) against carbamazepine (CBZ) and its metabolite carbamazepine-10, 11-epoxide (CBZ-EP). According to the results of our competitive enzyme-linked immunosorbent assay (ic-ELISA), the half-maximum inhibitory concentration values
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