62929

L-Lysine monohydrochloride

≥99.5% (AT), suitable for cell culture, BioUltra

• Synonym(s): (S)-2,6-Diaminohexanoic acid monohydrochloride
• Linear Formula: H₂N(CH₂)₄CH(NH₂)CO₂H·HCl
• CAS Number: 657-27-2
• Molecular Weight: 182.65
• NACRES: NA.26
• PubChem Substance ID: 329759756
• UNSPSC Code: 12352209
• EC Number: 211-519-9
• MDL number: MFCD00064564
• Beilstein/REAXYS Number: 3563889

Properties

• Product Name: L-Lysine monohydrochloride, BioUltra, ≥99.5% (AT)
• InChI key: BVHLGVCQOALMSV-JEDNCBNOSA-N
• InChI: 1S/C6H14N2O2.ClH/c7-4-2-1-3-5(8)6(9)10;/h5H,1-4,7-8H2,(H,9,10);1H/t5-;/m0./s1
• SMILES string: OC([C@@H](N)CCCCN)=O.[H]Cl
• product line: BioUltra
• assay: ≥99.5% (AT)
• form: powder or crystals
• optical activity: [α]20/D +20.5±0.5°, c = 5% in 5 M HCl
• technique(s): cell culture | mammalian: suitable
• impurities: insoluble matter, passes filter test; ≤0.3% foreign amino acids
• ign. residue: ≤0.1% (as SO₄)
• loss: ≤0.5% loss on drying, 20 °C (HV)
• color: white
• pH: 5.0-6.0 (25 °C, 0.5 M in H₂O)
• mp: 263 °C (dec.) (lit.)
• solubility: H₂O: 0.5 M at 20 °C, clear, colorless
• anion traces: sulfate (SO₄^2-): ≤100 mg/kg
• cation traces: Al: ≤5 mg/kg; As: ≤0.1 mg/kg; Ba: ≤5 mg/kg; Bi: ≤5 mg/kg; Ca: ≤10 mg/kg; Cd: ≤5 mg/kg; Co: ≤5 mg/kg; Cr: ≤5 mg/kg; Cu: ≤5 mg/kg; Fe: ≤5 mg/kg; K: ≤50 mg/kg; Li: ≤5 mg/kg; Mg: ≤5 mg/kg; Mn: ≤5 mg/kg; Mo: ≤5 mg/kg; NH₄⁺: ≤100 mg/kg; Na: ≤50 mg/kg; Ni: ≤5 mg/kg; Pb: ≤5 mg/kg; Sr: ≤5 mg/kg; Zn: ≤5 mg/kg
• λ: 0.5 M in H₂O
• UV absorption: λ: 260 nm A_max: 0.1; λ: 280 nm A_max: 0.1
• Quality Level: 200

Description

Application

L-Lysine monohydrochloride has been used:

• to study its effect on mRNA decay and destruction using mammalian cells[1]
• to determine its effec on aTC1-6 cell proliferation[2]
• to study the dynamics of the phosphoproteome upon amino acid supplement removal in the growth medium[3]

Biochem/physiol Actions

L-Lysine is associated with a number of biochemical reactions such as acetylation, O-linked glycosylation, ubiquitination and protein methylation. Lysine participates in the regulation of NO (nitric oxide) synthesis. It possesses antiviral activity, therefore it is used in the treatment of Herpes simplex.[4] L-Lysine is believed to prevent osteoporosis of bones, which is a characteristic of vascular calcification.[5] Glutaric aciduria type I and pyridoxine-dependent epilepsy occurs due to lack of L-lysine catabolic pathway.[6] Hydroxylysine is a component of collagen[4]

General description

L-Lysine is an essential amino acid, not generated by the body, instead must be supplemented through food.[4]

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)