63013

α₂-Macroglobulin from human plasma

≥90% (GE)

• Synonym(s): α₂-M
• CAS Number: 1631137-21-7
• MDL number: MFCD00130472
• NACRES: NA.61

Properties

• biological source: human plasma
• Quality Level: 100
• Assay: ≥90% (GE)
• mol wt: ~720 kDa (four glycoprotein subunits)
• technique(s): cell culture | mammalian: suitable
• solubility: H₂O: 1 mg/mL, clear to faintly turbid, colorless to faintly yellow
• UniProt accession no.: P01023
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: human ... A2M(2)

Description

Application

Inhibits all classes of endoproteases by forming a complex with the protease. When the protease cleaves the macroglobulin "bait" sequence, the macroglobulin rearranges and traps the protease.

Biochem/physiol Actions

α₂-Macroglobulin is found abundantly in plasma and interstitial fluids. The protease-α₂-M balance plays an important role in mediating inflammatory tissue destruction. Serum levels of α₂-M and protease-α₂-M complexes are increased in patients with sepsis, emphysema, periodontitis, rheumatoid arthritis, and other inflammatory diseases, and oxidant inactivation of α₂-M may contribute to tissue destruction during inflammation.

Analysis Note

100 mg solids are lyophilized with 1 mg glycine from 35.2 mL 30 mM sodium phosphate, pH 7.0

Plasma from each donor has been tested and found negative for antibody to HIV-1/HIV-2, antibody to HCV and HbSAg.

Other Notes

Conformational changes of α₂-M

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves