MilliporeSigma
All Photos(3)

65363

Supelco

(R)-(−)-α-Methoxy-α-(trifluoromethyl)phenylacetyl chloride

for chiral derivatization, LiChropur, ≥99.0%

Synonym(s):
(R)-(−)-MTPA-Cl, Mosher’s acid chloride
Linear Formula:
C6H5C(OCH3)(CF3)COCl
CAS Number:
Molecular Weight:
252.62
Beilstein:
3591563
MDL number:
PubChem Substance ID:

grade

for chiral derivatization

Quality Level

product line

ChiraSelect

assay

≥99.0% (AT)
≥99.0%

optical activity

[α]20/D −137±2°, c = 6.4% in carbon tetrachloride

optical purity

enantiomeric ratio: ≥99.5:0.5 (GC)

quality

LiChropur

technique(s)

HPLC: suitable

refractive index

n20/D 1.469
n20/D 1.47 (lit.)

bp

213-214 °C (lit.)

density

1.35 g/mL at 25 °C (lit.)

shipped in

wet ice

storage temp.

−20°C

SMILES string

CO[C@](C(Cl)=O)(c1ccccc1)C(F)(F)F

InChI

1S/C10H8ClF3O2/c1-16-9(8(11)15,10(12,13)14)7-5-3-2-4-6-7/h2-6H,1H3/t9-/m0/s1

InChI key

PAORVUMOXXAMPL-VIFPVBQESA-N

Looking for similar products? Visit Product Comparison Guide

General description

(R)-(-)-a-Methoxy-a-(trifluoromethyl)phenylacetyl chloride (Mosher′s acid chloride) is generally used as a chiral derivatizing agent. It is easily available in enantiomerically pure form. It can form diastereomers with both alcohols and amines.

Application

It was used for derivatizing D-arabinitol and L-arabinitol samples for high performance thin layer chromatography (HPTLC) analysis for studying resolution of the diastereoisomer.
Ready-to-use reagent for the determination of the enantiomeric purity of alcohols and amines after derivatization; doi:10.1038/nprot.2007.354

Packaging

100, 500 mg in glass bottle
Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Please note that R(-)-MTPA-Cl is derived from S(-)-MTPA

Recommended products

Discover LiChropur reagents ideal for HPLC or LC-MS analysis

Legal Information

ChiraSelect is a trademark of Sigma-Aldrich Co. LLC
LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Corrosion

Signal Word

Danger

Hazard Statements

Hazard Classifications

Skin Corr. 1B

Storage Class Code

8A - Combustible, corrosive hazardous materials

WGK

WGK 3

Flash Point(F)

192.2 °F - closed cup

Flash Point(C)

89 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service