Skip to Content
MilliporeSigma
All Photos(5)

Documents

673277

Sigma-Aldrich

2-Methyltetrahydrofuran

greener alternative

BioRenewable, anhydrous, ≥99%, Inhibitor-free

Synonym(s):

2-MeTHF, Tetrahydro-2-methylfuran, Tetrahydrosilvan

Sign Into View Organizational & Contract Pricing


About This Item

Empirical Formula (Hill Notation):
C5H10O
CAS Number:
Molecular Weight:
86.13
Beilstein/REAXYS Number:
102448
EC Number:
MDL number:
UNSPSC Code:
12352005
PubChem Substance ID:
NACRES:
NA.21

grade

anhydrous

Quality Level

assay

≥99%

form

liquid

expl. lim.

0.34-6.3 % (lit.)

greener alternative product characteristics

Safer Solvents and Auxiliaries
Use of Renewable Feedstocks
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

impurities

≤0.002% water
≤0.005% water (100 mL pkg)

evapn. residue

≤0.0003%

refractive index

n20/D 1.406 (lit.)

bp

78-80 °C (lit.)

mp

-136 °C (lit.)

density

0.86 g/mL at 25 °C (lit.)

greener alternative category

SMILES string

CC1CCCO1

InChI

1S/C5H10O/c1-5-3-2-4-6-5/h5H,2-4H2,1H3

InChI key

JWUJQDFVADABEY-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

General description

We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product is a biorenewable and thus aligns with "Safer Solvents and Auxiliaries" and "Use of Renewable Feedstocks". Click here for more information.
2-Methyltetrahydrofuran (2-MTHF), a 2-methyl substituted tetrahydrofuran, is a biomass derived solvent. It is a potential greener solvent alternative for organic synthesis. It shows resistance to reduction by lithium making it a promising candidate as electrolytes in lithium batteries. Its polarity and Lewis base strength is intermediate between tetrahydrofuran (THF) and diethyl ether. The ring opening reaction of 2-MTHF has been studied using acid chloride and iodide.

Application

2-Methyltetrahydrofuran may be used as a solvent for phosphatidylserine synthesis.
It may be used as an alternative solvent to:
  • Dimethyl sulfoxide (DMSO) or methyl tert-butyl ether (MTBE) in the C-C bond forming reactions catalyzed by lyase enzyme.
  • Tetrahydrofuran (THF) in the reaction between Grignard reagents and carbonyl compounds.
  • Methylene chloride in some biphasic reactions.
Green Alternatives to DCM and THF from Renewable Resources

Organic Solar Cells

2-Methyltetrahydrofuran (2-MeTHF): A Biomass-Derived Solvent with Broad Application in Organic Chemistry

Features and Benefits

Greener alternative for THF, DCM, DMSO, and MTBE

related product

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 2 - Skin Irrit. 2

supp_hazards

wgk_germany

WGK 2

flash_point_f

14.0 °F

flash_point_c

-10.0 °C

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter


Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Customers Also Viewed

Slide 1 of 4

1 of 4

Cyrene™ BioRenewable, DMF and NMP Substitute

Sigma-Aldrich

807796

Cyrene

Tetrahydrofuran anhydrous, ≥99.9%, inhibitor-free

Sigma-Aldrich

401757

Tetrahydrofuran

Renxi Jin et al.
Nanoscale, 9(48), 19183-19190 (2017-12-01)
Doping metal nanoclusters with a second type of metal is a powerful method for tuning the physicochemical properties of nanoclusters at the atomic level and it also provides opportunities for a fundamental understanding of alloying rules as well as new
Biorenewable Solvents for High-Performance Organic Solar Cells
Panidi J, et al.
ACS Energy Letters, 8, 3038-3047 (2023)
Birte Riechers et al.
Physical chemistry chemical physics : PCCP, 21(1), 32-37 (2018-10-03)
We observe structural recovery after an electric field step by probing the dielectric loss profile near its maximum, which displays a field-induced shift towards lower frequencies. These dynamics display time aging-time superposition (TaTS) for the majority of relaxation modes, thus
Dennis Weidener et al.
Molecules (Basel, Switzerland), 25(15) (2020-07-28)
Fractionation of lignocellulose into its three main components, lignin, hemicelluloses, and cellulose, is a common approach in modern biorefinery concepts. Whereas the valorization of hemicelluloses and cellulose sugars has been widely discussed in literature, lignin utilization is still challenging. Due
2-Methyltetrahydrofuran (2-MeTHF): A Biomass-Derived Solvent with Broad Application in Organic Chemistry.
Pace V, et al.
ChemSusChem, 5(8), 1369-1379 (2012)

Related Content

Why should you have to choose between solvents that are ecological and those that are reliable? Enjoy both at once with our biorenewable and greener solutions. Cyrene™ solvent is a new dipolar aprotic alternative to common REACH restricted solvents, such as N methyl-2-pyrrolidone (NMP) and Dimethylformamide (DMF).

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service