Ammonium formate

eluent additive for LC-MS, LiChropur, ≥99.0%

Formic acid ammonium salt
Linear Formula:
CAS Number:
Molecular Weight:
Beilstein/REAXYS Number:
EC Number:
MDL number:
PubChem Substance ID:

Quality Level


eluent additive for LC-MS




≥99.0% (calc. on dry substance, NT)




HPLC: suitable
LC/MS: suitable


insoluble matter, passes filter test
<2% water

ign. residue (900 °C)

<0.1% (as SO4)


5.5-7.5 (25 °C, 1 M in H2O)


119-121 °C (lit.)


H2O: 1 M at 20 °C, clear, colorless


1.26 g/mL at 25 °C (lit.)

anion traces

chloride (Cl-): ≤50 mg/kg
sulfate (SO42-): ≤50 mg/kg

cation traces

Al: ≤1 mg/kg
As: ≤0.1 mg/kg
Ba: ≤1 mg/kg
Bi: ≤1 mg/kg
Ca: ≤5 mg/kg
Cd: ≤1 mg/kg
Co: ≤1 mg/kg
Cr: ≤1 mg/kg
Cu: ≤1 mg/kg
Fe: ≤1 mg/kg
K: ≤5 mg/kg
Li: ≤1 mg/kg
Mg: ≤1 mg/kg
Mn: ≤1 mg/kg
Mo: ≤1 mg/kg
Na: ≤5 mg/kg
Ni: ≤1 mg/kg
Pb: ≤1 mg/kg
Sr: ≤1 mg/kg
Zn: ≤1 mg/kg


1 M in H2O

UV absorption

λ: 260 nm Amax: ≤0.01
λ: 280 nm Amax: ≤0.01

SMILES string




InChI key


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General description

Ammonium formate is the ammonium salt of formic acid. It is readily available, is stable and nontoxic in nature. It can be used in conjugation with Palladium on carbon (Pd-C) or Raney-Nickel catalysts.


Ammonium formate has been used as buffer solution during LC-MS/MS analysis for screening of drugs and exogenous compounds. It may be used as a catalytic hydrogen transfer agent in reduction of aliphatic and aromatic nitro compounds.
Ammonium formate has been used as buffer solution during LC-MS/MS analysis for screening of drugs and exogenous compounds. It may be used as a catalytic hydrogen transfer agent in reduction of aliphatic and aromatic nitro compounds.
Ammonium formate has been used in the separation of non-steroidal anti-inflammatory drugs and of oligosaccharide mixtures using capillary electrochromatography. It is also used in the analysis of phosphatidylserines, triacylglycerols and triacylglycerol oxidation products, and oligogalacturonic acids using HPLC and HPLC-MS methods.

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany


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Signal Word


Hazard Statements

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves


NONH for all modes of transport

WGK Germany


Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

François-Ludovic Sauvage et al.
Clinical chemistry, 52(9), 1735-1742 (2006-07-22)
In clinical and forensic toxicology, general unknown screening is used to detect and identify exogenous compounds. In this study, we aimed to develop a comprehensive general unknown screening method based on liquid chromatography coupled with a hybrid triple-quadrupole linear ion...
A general procedure for mild and rapid reduction of aliphatic and aromatic nitro compounds using ammonium formate as a catalytic hydrogen transfer agent.
Ram, Siya, and Richard E. Ehrenkaufer.
Tetrahedron Letters, 25.32, 3415-3418 (1984)
Jiang-Tao Niu et al.
Evidence-based complementary and alternative medicine : eCAM, 2020, 4543761-4543761 (2020-12-22)
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Anne M Filppula et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(7), 1202-1209 (2014-04-10)
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Therese Fagerqvist et al.
Journal of neurochemistry, 126(1), 131-144 (2013-02-01)
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