73177

Supelco

1-Fluoro-2,4-dinitrobenzene

for HPLC derivatization, LiChropur, ≥99.0% (GC)

Synonym(s):
Sanger reagent, DNFB, DNPF, FDNB, 2,4-Dinitro-1-fluorobenzene
Linear Formula:
(O2N)2C6H3F
CAS Number:
Molecular Weight:
186.10
Beilstein/REAXYS Number:
398632
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22

Quality Level

grade

for HPLC derivatization

assay

≥99.0% (GC)

quality

LiChropur

application(s)

HPLC: suitable

refractive index

n20/D 1.569 (lit.)

bp

178 °C/25 mmHg (lit.)

mp

25-27 °C (lit.)

density

1.482 g/mL at 25 °C (lit.)

SMILES string

[O-][N+](=O)c1ccc(F)c(c1)[N+]([O-])=O

InChI

1S/C6H3FN2O4/c7-5-2-1-4(8(10)11)3-6(5)9(12)13/h1-3H

InChI key

LOTKRQAVGJMPNV-UHFFFAOYSA-N

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General description

1-Fluoro-2,4-dinitrobenzene is a color labeling agent, mainly used for detecting primary and secondary amines.

Application

1-Fluoro-2,4-dinitrobenzene may be used as a derivatizing reagent for the determination of gabapentin in human plasma samples, pharmaceutical formulations and memantine hydrochloride in pharmaceutical formulations using high-performance liquid chromatography technique.

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Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Exclamation markHealth hazard

Signal Word

Warning

Target Organs

Respiratory system

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

327.2 °F

Flash Point(C)

164 °C

Certificate of Analysis

Certificate of Origin

Validated HPLC method for the determination of gabapentin in human plasma using pre-column derivatization with 1-fluoro-2, 4-dinitrobenzene and its application to a pharmacokinetic study
Jalalizadeh H, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 854(1-2), 43-47 (2007)
A stability-indicating HPLC method for the determination of memantine hydrochloride in dosage forms through derivatization with 1-fluoro-2, 4-dinitrobenzene
Jalalizadeh H, et al.
Scientia Pharmaceutica, 82(2), 265-280 (2014)
Optimization of an HPLC method for determination of gabapentin in dosage forms through derivatization with 1-fluoro-2, 4-dinitrobenzene
Souri E, et al.
Chemical & Pharmaceutical Bulletin, 55(10), 1427-1430 (2007)
Helena Shifrin et al.
PloS one, 8(2), e57668-e57668 (2013-03-08)
The cholinergic anti-inflammatory system and α7 nicotinic receptors in macrophages have been proposed to play a role in neuroimmunomodulation and in the etiology of ulcerative colitis. We investigated the ability of a cholinesterase (ChE) inhibitor rivastigmine, to improve the pathology...
Ming-Feng Chiang et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(16), 6476-6481 (2013-04-12)
B lymphocyte-induced maturation protein-1 (Blimp-1) is a transcriptional repressor important for the differentiation and function of several types of immune cells. Because skin serves as a physical barrier and acts as an immune sentinel, we investigated whether Blimp-1 is involved...

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