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74202

Supelco

Tetramethylammonium chloride

suitable for ion pair chromatography, LiChropur, ≥99.0% (AT)

Synonym(s):
TMA
Linear Formula:
(CH3)4N(Cl)
CAS Number:
Molecular Weight:
109.60
Beilstein:
3911201
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NB.21

Quality Level

description

cationic

assay

≥99.0% (AT)

quality

LiChropur

technique(s)

ion pair chromatography: suitable

mp

>300 °C (lit.)

λ

10 % in H2O

UV absorption

λ: 220 nm Amax: 0.05
λ: 230 nm Amax: 0.04
λ: 250 nm Amax: 0.03
λ: 260 nm Amax: 0.02
λ: 500 nm Amax: 0.02

suitability

corresponds to standard for RP gradient test
corresponds to standard for filter test

SMILES string

[Cl-].C[N+](C)(C)C

InChI

1S/C4H12N.ClH/c1-5(2,3)4;/h1-4H3;1H/q+1;/p-1

InChI key

OKIZCWYLBDKLSU-UHFFFAOYSA-M

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General description

Tetramethylammonium chloride (TMAC) is structurally similar to alkyltrimethylammonium salts. Oxidation of TMAC yields formaldehyde and trimethlamine. It is considered as poor phase-transfer catalyst for most reactions as it is insoluble in organic media. However, it is highly suitable as phase-transfer catalyst for fluorination of chlorobenzaldehydes along with alkali metal fluorides which yield 1,2,2,2-tetrafluoroethyldifluoromethyl ether.

Application

TMAC may be used in ion-exchange procedures to show the increase of pH in understanding the chemical behaviour of catalyst [CTA]Si-MCM-41 using Knoevenagel condensation model.

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Signal Word

Danger

Hazard Classifications

Acute Tox. 2 Oral - Acute Tox. 3 Dermal - Aquatic Chronic 2 - Skin Irrit. 2 - STOT SE 1 Oral

Target Organs

Central nervous system

Storage Class Code

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 1

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

Certificate of Origin

Fundamentals, Applications, and Industrial Perspectives
C.M. Starks, M. Halper
Phase Transfer Catalysis (Academic Press), 182 -182 (2012)
Surfactant containing Si-MCM-41: An efficient basic catalyst for the Knoevenagel condensation.
Martins, Leandro, et al.
Applied Catalysis A: General, 312, 77-85 (2006)
Markus Welcker et al.
Genes & development, 27(23), 2531-2536 (2013-12-04)
The Fbw7 tumor suppressor targets a broad network of proteins for ubiquitylation. Here we show critical functions for Fbw7 dimerization in regulating the specificity and robustness of degradation. Dimerization enables Fbw7 to target substrates through concerted binding to two suboptimal
Wei Shen et al.
Chemical communications (Cambridge, England), 49(73), 8114-8116 (2013-08-08)
A simple and low-cost colorimetric assay utilizing ferrofluidic nanoparticulate probes (FNPs) and a ligase for single-nucleotide polymorphism genotyping is described. Excellent sensitivity and selectivity were accomplished through the engagement of the FNPs and a ligase chain reaction.
Marco I Ries et al.
The Journal of biological chemistry, 288(52), 37289-37295 (2013-11-15)
Metabolic profiling and structural elucidation of novel secondary metabolites obtained from derived deletion strains of the filamentous fungus Penicillium chrysogenum were used to reassign various previously ascribed synthetase genes of the roquefortine/meleagrin pathway to their corresponding products. Next to the

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