77608

Sigma-Aldrich

Phenol

BioUltra, for molecular biology, ≥99.5% (GC)

Synonym(s):
Hydroxybenzene
Linear Formula:
C6H5OH
CAS Number:
Molecular Weight:
94.11
Beilstein/REAXYS Number:
969616
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.25

Quality Level

grade

for molecular biology

vapor density

3.24 (vs air)

vapor pressure

0.09 psi ( 55 °C)
0.36 mmHg ( 20 °C)

product line

BioUltra

assay

≥99.5% (GC)

form

solid

autoignition temp.

1319 °F

contains

~0.15% hypophosphorous acid as stabilizer

expl. lim.

8.6 %

impurities

DNases, none detected
RNases, none detected
insoluble matter, passes filter test
phosphatases, none detected
proteases, none detected
≤0.5% water

ign. residue

≤0.05%

pH

3.0-6.0 (25 °C, 0.5 M in H2O)

bp

182 °C (lit.)

mp

40-42 °C (lit.)
40-42 °C

solubility

H2O: 0.5 M at 20 °C, clear, colorless

density

1.071 g/mL at 25 °C (lit.)

anion traces

chloride (Cl-): ≤5 mg/kg
sulfate (SO42-): ≤50 mg/kg

cation traces

Al: ≤5 mg/kg
As: ≤0.1 mg/kg
Ba: ≤5 mg/kg
Bi: ≤5 mg/kg
Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Li: ≤5 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Mo: ≤5 mg/kg
Na: ≤50 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Sr: ≤5 mg/kg
Zn: ≤5 mg/kg

SMILES string

Oc1ccccc1

absorption

cut-off at 294 nm in H2O at 0.5 M

suitability

suitable for molecular biology

storage temp.

2-8°C

InChI

1S/C6H6O/c7-6-4-2-1-3-5-6/h1-5,7H

InChI key

ISWSIDIOOBJBQZ-UHFFFAOYSA-N

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General description

Phenol/carbolic acid is mainly produced by hospital pharmacy as it is unavailable in premixed liquid form. It is not highly soluble in water. Phenol should be refrigerated and protected from light exposure to maintain its shelf life of approximately one year. Kidneys can excrete phenol as several conjugated derivatives.

Application

Phenol has been used in the incubation of pellet for RNA extraction.

Biochem/physiol Actions

Phenol has the ability to denature protein, hence can lead to denervation. At lower concentration, it can serve as a local anaesthetic and can also act as a neurolytic agent in higher concentration. It is also linked with tissue damage at higher concentrations.

Other Notes

For the preparation of DNA ; Large- and small-scale phenol extractions

Signal Word

Danger

hazcat

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Muta. 2 - Skin Corr. 1B - STOT RE 2

storage_class_code

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK Germany

WGK 2

Flash Point(F)

174.2 °F - closed cup

Flash Point(C)

79.0 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Telomere length determines TERRA and R-loop regulation through the cell cycle
Graf M, et al.
Cell, 170(1), 72-85 (2017)
Neural blockade with neurolytic agents
Pain management, 343-348 (2007)
Commonly Used Medications in Procedures
Pain Procedures in Clinical Practice, 2-2 (2011)
Current Protocols in Molecular Biology (1987)
Chemical neurolytic blocks
Practical Management of Pain, 784-793 (2013)

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