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78445

Tetrahydrofuran

analytical standard

Synonym(s):

Butylene oxide, Oxolane, Tetramethylene oxide

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Pack SizeSKUAvailabilityPrice
5 mL

Available to ship TODAYfromMILWAUKEE

$81.80

About This Item

Empirical Formula (Hill Notation):
C4H8O
CAS Number:
Molecular Weight:
72.11
UNSPSC Code:
12191501
NACRES:
NA.24
PubChem Substance ID:
EC Number:
203-726-8
Beilstein/REAXYS Number:
102391
MDL number:

$81.80


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grade

analytical standard

Quality Level

vapor density

2.5 (vs air)

vapor pressure

114 mmHg ( 15 °C), 143 mmHg ( 20 °C)

assay

≥99.9% (GC)

autoignition temp.

610 °F

shelf life

limited shelf life, expiry date on the label

contains

~0.025% 2,6-di-tert.-butyl-4-methylphenol as stabilizer

expl. lim.

1.8-11.8 %

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

refractive index

n20/D 1.407 (lit.)

bp

65-67 °C (lit.)

mp

−108 °C (lit.)

solubility

H2O: soluble

density

0.889 g/mL at 25 °C (lit.)

application(s)

cleaning products
cosmetics
environmental
food and beverages
personal care

format

neat

SMILES string

C1CCOC1

InChI

1S/C4H8O/c1-2-4-5-3-1/h1-4H2

InChI key

WYURNTSHIVDZCO-UHFFFAOYSA-N

General description

Tetrahydrofuran (THF) is a saturated cyclic ether. Its potential use as a biofuel for internal combustion engines is investigated.
Tetrahydrofuran is an important basic chemical compound, which belongs to the category of 5-membered heterocycles.[1]
This substance is listed on the positive list of the EU regulation 10/2011 for plastics intended to come into contact with food. Find all available reference materials for compounds listed in 10/2011 here

Application

Tetrahydrofuran may be used as an extraction solvent for the determination of pesticide residues in olive oil and phthalates in toys and child care articles by chromatography techniques.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Tetrahydrofuran may find application as a solvent in the synthesis of (S)-2-(1-pyrrolidinylmethyl)pyrrolidine. It is also an excellent solvent for sodium diisopropylamide, which can find applications as an effective base for the isomerization of alkenes and metalation of 1,4-dienes.[1]

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This Item
RTC000088348651.09731
technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

technique(s)

HPLC: suitable

technique(s)

-

application(s)

cleaning products
cosmetics
environmental
food and beverages
personal care

application(s)

pharmaceutical small molecule

application(s)

food and beverages

application(s)

-

format

neat

format

-

format

-

format

-

Quality Level

100

Quality Level

300

Quality Level

100

Quality Level

300

grade

analytical standard

grade

certified reference material, pharmaceutical secondary standard

grade

HPLC grade

grade

ACS reagent

assay

≥99.9% (GC)

assay

-

assay

≥99.9%

assay

≥99.8% (GC)


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signalword

Danger

target_organs

Central nervous system, Respiratory system

supp_hazards

Storage Class

3 - Flammable liquids

flash_point_f

-6.2 °F - closed cup

flash_point_c

-21.2 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - STOT SE 3



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Certificates of Analysis (COA)

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Articles

Learn about analyzing organic volatile impurities (OVIs) in pharmaceuticals using SH-GC, focusing on suitable solvents and ensuring compliance.


Hayashi T, et al. et al.
Asymmetric Synthesis: Graphical Abstracts and Experimental Methods (1998)
Simultaneous GC?MS determination of eight phthalates in total and migrated portions of plasticized polymeric toys and childcare articles
Al-Natsheh M, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 985, 103-109 (2015)
Direct Functionalization of Tetrahydrofuran and 1, 4-Dioxane: Nickel-Catalyzed Oxidative C (sp3) H Arylation
Liu D, et al.
Angewandte Chemie (International Edition in English), 52(16), 4453-4456 (2013)



Global Trade Item Number

SKUGTIN
78445-5ML-F04061832946580

Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

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