All Photos(4)

791962

Sigma-Aldrich

Cyclopentyl methyl ether

greener alternative

inhibitor-free, anhydrous, ≥99.9%

Synonym(s):
CPME, CMPE
Empirical Formula (Hill Notation):
C6H12O
CAS Number:
Molecular Weight:
100.16
MDL number:
PubChem Substance ID:
NACRES:
NA.21

Quality Level

grade

anhydrous

assay

≥99.9%

form

liquid

greener alternative product characteristics

Safer Solvents and Auxiliaries
Learn more about the Principles of Green Chemistry.

impurities

≤0.0050% water
water

bp

106 °C/760 mmHg

mp

-140 °C (lit.)

density

0.86 g/mL at 25 °C

greener alternative category

Aligned

SMILES string

COC1CCCC1

InChI

1S/C6H12O/c1-7-6-4-2-3-5-6/h6H,2-5H2,1H3

InChI key

SKTCDJAMAYNROS-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

General description

We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. Cyclopentyl methyl ether (CPME) is a greener alternative to other ethereal solvents such as tetrahydrofuran (THF), 2-methyl tetrahydrofuran (2-MeTHF), dioxane (carcinogenic), tert-Butyl methyl ether (MTBE), and 1,2-dimethoxyethane (DME) and thus has been enhanced for "Safer Solvents and Auxiliaries". Click here for more information.

Application

  • Cyclopentyl methyl ether (CPME) is an alternative to ether solvents such as THF, diethyl ether, and MTBE with a higher resistance to peroxide formation.
  • The more environmentally conservative CPME solvent replaces hazardous solvents in order to achieve sustainability and reduce environmental and operational costs.
  • CPME offers considerable potential and advantage as a direct replacement for CH2Cl2 in binary eluents using MeOH as the modifier with MeOH–DMC and i-PrOH–EtOAc.

Packaging

1, 2 L in Sure/Seal™
100 mL in Sure/Seal™

Features and Benefits

Greener alternative for THF, diethyl ether, and MTBE

Pictograms

FlameExclamation mark

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2 - Skin Irrit. 2

Storage Class Code

3 - Flammable liquids

WGK Germany

WGK 3

Flash Point(F)

37.4 °F - closed cup

Flash Point(C)

< 3 °C - closed cup

Certificate of Analysis

Certificate of Origin

Watanabe, K.;
Organic Process Research & Development, 11 (2007)
MacMillan, D. S. ;
Green Chemistry (2012)
Rikako Takahiro et al.
Biological & pharmaceutical bulletin, 38(1), 58-65 (2015-03-07)
The aim of this study was to characterize the kinetics of metabolite formation of the phosphodiesterase type-5 (PDE5) inhibitors sildenafil and tadalafil by CYP3A4, CYP3A5, and CYP3A7 isoforms. The formations of N-desmethyl sildenafil and desmethylene tadalafil were examined using CYP3A...

Related Content

Biorenewable Solvents

Why should you have to choose between solvents that are ecological and those that are reliable? Enjoy both at once with our biorenewable and greener solutions. Cyrene™ solvent is a new dipolar aprotic alternative to common REACH restricted solvents, such as N methyl-2-pyrrolidone (NMP) and Dimethylformamide (DMF).

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service