80073

Supelco

α-Hydroxymetoprolol

analytical standard

Synonym(s):
3-4-(1-Hydroxy-2-methoxyethyl)phenoxy-1-isopropylamino-2-propanol, 4-{2-Hydroxy-3-(1-methylethyl)aminopropoxy}-α-(methoxymethyl)-benzenemethanol
Empirical Formula (Hill Notation):
C15H25NO4
CAS Number:
Molecular Weight:
283.36
Beilstein/REAXYS Number:
6571082
MDL number:
PubChem Substance ID:
NACRES:
NA.24
Pricing and availability is not currently available.

Quality Level

grade

analytical standard

assay

≥98.0% (HPLC)

form

neat

CofA

certificate is enclosed in each package

shelf life

limited shelf life, expiry date on the label

application(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

68-74 °C

Featured Industry

Forensics and Toxicology
Pharmaceutical (small molecule)

format

neat

SMILES string

OC(CNC(C)C)COC1=CC=C(C(O)COC)C=C1

InChI

1S/C15H25NO4/c1-11(2)16-8-13(17)9-20-14-6-4-12(5-7-14)15(18)10-19-3/h4-7,11,13,15-18H,8-10H2,1-3H3

InChI key

OFRYBPCSEMMZHR-UHFFFAOYSA-N

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Diego Alberto Ciscato Cusinato et al.
Journal of pharmaceutical and biomedical analysis, 164, 430-441 (2018-11-18)
Drug transporters and CYP enzymes are important sources of pharmacokinetics (PK) variability in drug responses and can cause various pharmacological and toxicological consequences, leading to either toxicity or an insufficient pharmacological effect. In recent years, the cocktail approach was developed...
L Labbé et al.
Pharmacogenetics, 10(5), 425-438 (2000-07-18)
The effects of gender, time variables, menstrual cycle phases, plasma sex hormone concentrations and physiologic urinary pH on CYP2D6 phenotyping were studied using two widely employed CYP2D6 probe drugs, namely dextromethorphan and metoprolol. Phenotyping on a single occasion of 150...
Nattee Sirisuth et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 53(3), 301-309 (2002-04-27)
To investigate the influence of alpha-hydroxymetoprolol (AHM) and 4-(2-hydroxy-3-isopropylaminopropoxy)-phenylacetic acid (ACMB), both derived from its first pass metabolism of metoprolol, an in vitro in vivo correlation incorporating first pass metabolite data for metoprolol extended release formulations was developed. Three different...
Vanessa Bergamin Boralli et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 823(2), 195-202 (2005-07-21)
We investigated the stereoselective kinetic disposition and metabolism of metoprolol (MET) in rats. The racemic MET (15 mg/kg) was given by oral gavage and blood samples were collected from 0 to 10h (n=6 at each time point). The enantiomeric concentrations...
D R Sohn et al.
Therapeutic drug monitoring, 14(3), 184-189 (1992-06-01)
We examined the utility of the postdose 3-h plasma metabolic ratio (MR) as a phenotyping method for assessing genetically determined debrisoquine-type oxidation polymorphism after an oral dose of 100 mg of metoprolol tartrate administered to 402 unrelated, healthy, and native...

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