80714

Supelco

Tanshinone I

analytical standard

Synonym(s):
Tanshinquinone I, Tanshinone A, Tanshinon I
Empirical Formula (Hill Notation):
C18H12O3
CAS Number:
Molecular Weight:
276.29
MDL number:
PubChem Substance ID:
NACRES:
NA.24
Pricing and availability is not currently available.

Quality Level

grade

analytical standard

assay

≥98.0% (HPLC)

form

neat

CofA

certificate is enclosed in each package

shelf life

limited shelf life, expiry date on the label

application(s)

HPLC: suitable
gas chromatography (GC): suitable

Featured Industry

Food and Beverages

format

neat

storage temp.

2-8°C

SMILES string

Cc1coc2-c3ccc4c(C)cccc4c3C(=O)C(=O)c12

InChI

1S/C18H12O3/c1-9-4-3-5-12-11(9)6-7-13-15(12)17(20)16(19)14-10(2)8-21-18(13)14/h3-8H,1-2H3

InChI key

AIGAZQPHXLWMOJ-UHFFFAOYSA-N

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General description

Tanshinone I is a bioconstituent, belonging to the class of tanshinone compounds isolated from Salvia miltiorrhiza Bunge. It is commonly used to dilate coronary arteries, increase coronary flow, modulate mutagenic activity and protect the myocardium against ischaemia.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Tanshinone I may be used as an analytical reference standard for the quantification of the analyte in pharmaceutical formulations and roots of Salvia miltiorrhiza using different chromatography techniques.

Biochem/physiol Actions

Phenanthrenequinone constituent of Chinese medicinal herb Danshen (Salvia miltiorrhiza). Modulates or prevents breast cancer metastasis by regulating adhesion molecules. Anti-inflammatory.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Development of the fingerprints for the quality of the roots of Salvia miltiorrhiza and its related preparations by HPLC-DAD and LC-MSn
Liu H-A, et al.
Journal of Chromatography. B, Biomedical Applications, 846(1-2), 32-41 (2007)
Qing Cai et al.
Chinese journal of integrative medicine, 18(11), 837-845 (2012-10-23)
To investigate the protective effects of sodium tanshinone B (STB) on brain damage following focal ischemia-reperfusion (I/R) injury through interfering with N-methyl-D-aspartic acid receptor (NMDAR) and excitatory and inhibitory amino acids, and evaluate the potential mechanisms of the neuroprotective activity...
Ying Luo et al.
PloS one, 8(2), e56774-e56774 (2013-02-26)
We previously showed that tanshinone IIA ameliorated the hypoxia-induced pulmonary hypertension (HPH) partially by attenuating pulmonary artery remodeling. The hypoxia-induced proliferation of pulmonary artery smooth muscle cells (PASMCs) is one of the major causes for pulmonary arterial remodeling, therefore the...
Yan-Ling Li et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(5), 678-682 (2013-06-04)
To study the application of degrading multi-enzymes from Ganoderma lucidum in extracting effective constituents from fibrous roots of Salvia miltiorrhiza. Effective constituents were extracted from fibrous roots by degrading multi-enzymes of wood fiber. The enzymatic parameters were optimized by the...
Wen-Quan Wang et al.
Journal of hematology & oncology, 5, 69-69 (2012-11-10)
Promotion of endothelial normalization restores tumor oxygenation and obstructs tumor cells invasion, intravasation, and metastasis. We therefore investigated whether a vasoactive drug, tanshinone IIA, could inhibit metastasis by inducing vascular normalization after palliative resection (PR) of hepatocellular carcinoma (HCC). A...

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