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81242

Sigma-Aldrich

Poly(ethylene glycol)

tested according to Ph. Eur., 4,000

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Synonym(s):
Macrogol 4,000, PEG
Linear Formula:
H(OCH2CH2)nOH
CAS Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.21

Agency

tested according to Ph. Eur.

Quality Level

form

solid

mol wt

3500-4500

application(s)

pharmaceutical (small molecule)

SMILES string

C(CO)O

InChI

1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2

InChI key

LYCAIKOWRPUZTN-UHFFFAOYSA-N

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1 of 4

This Item
8128081240202398
Poly(ethylene glycol) tested according to Ph. Eur., 4,000

Sigma-Aldrich

81242

Poly(ethylene glycol)

Poly(ethylene glycol) 10,000

Sigma-Aldrich

81280

Poly(ethylene glycol)

Poly(ethylene glycol) average Mn 4,000, platelets

Sigma-Aldrich

81240

Poly(ethylene glycol)

Poly(ethylene glycol) average Mn 400

Sigma-Aldrich

202398

Poly(ethylene glycol)

mol wt

3500-4500

mol wt

8500-11500

mol wt

Mn 3,500-4,500, average Mn 4,000

mol wt

Mn 380-420, average Mn 400

Quality Level

200

Quality Level

200

Quality Level

-

Quality Level

200

agency

tested according to Ph. Eur.

agency

-

agency

-

agency

-

application(s)

pharmaceutical (small molecule)

application(s)

-

application(s)

-

application(s)

-

General description

Poly(ethylene glycol) (PEG) is a non-toxic water-soluble polymer. PEG term is used for the polymer chains with molecular weights below 20 000, while poly(ethylene oxide) (PEO) refers to the higher molecular weight polymers. PEG has various biomedical applications. It forms complexes with α-cyclodextrins. Engineering of PEG hydrogel particles by mesoporous silica (MS) templating method has been reported.

Application

Poly(ethylene glycol) may be used in the following studies:
  • For the modification of proteins to form the conjugates having increased circulating life and reduced immunogenicity and antigenicity.
  • Preparation of hydrogels useful for the diffusion controlled delivery of proteins.
  • Preparation of poly(ethylene glycol) dimethacrylate (PEGDM).

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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25G
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705578-5MG-PW

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MMYOMAG-74K-13

1000309185

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Poly(ethylene glycol)

The clinical efficacy of poly (ethylene glycol)-modified proteins.
Fuertges F and Abuchowski A.
Journal of Controlled Release : Official Journal of the Controlled Release Society, 11(1), 139-148 (1990)
Stephanie J Bryant et al.
Annals of biomedical engineering, 32(3), 407-417 (2004-04-21)
In approaches to tissue engineer articular cartilage, an important consideration for in situ forming cell carriers is the impact of mechanical loading on the cell composite structure and function. Photopolymerized hydrogel scaffolds based on poly(ethylene glycol) (PEG) may be synthesized
N A Peppas et al.
Journal of controlled release : official journal of the Controlled Release Society, 62(1-2), 81-87 (1999-10-16)
The use of hydrogels as carriers for protein delivery has been a subject of significant recent research. In our recent work, we have shown that diffusion controlled delivery of proteins from hydrogels containing poly(ethylene glycol) (PEG) can be possible and
Complex formation between poly (ethylene glycol) and α-cyclodextrin.
Harada A and Kamachi M.
Macromolecules, 23(10), 2821-2823 (1990)
Mark A Rice et al.
Acta biomaterialia, 5(1), 152-161 (2008-09-17)
Ultrasound has potential as a non-destructive analytical technique to provide real-time online assessments of matrix evolution in cell-hydrogel constructs used in tissue engineering. In these studies, chondrocytes were encapsulated in poly(ethylene glycol) hydrogels, and gel degradation was manipulated to provide

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