83700

Supelco

Rhodanine

for spectrophotometric det. of gallic acid, ≥99.0%

Synonym(s):
2-Thioxo-4-thiazolidinone
Empirical Formula (Hill Notation):
C3H3NOS2
CAS Number:
Molecular Weight:
133.19
Beilstein/REAXYS Number:
110701
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.21

Quality Level

assay

≥99.0% (HPLC)
≥99.0%

quality

for spectrophotometric det. of gallic acid

application(s)

UV/Vis spectroscopy: suitable

mp

165-169 °C (lit.)
165-169 °C

solubility

methanol: 0.5 g/10 mL, clear, colorless to greenish-yellow

SMILES string

O=C1CSC(=S)N1

InChI

1S/C3H3NOS2/c5-2-1-7-3(6)4-2/h1H2,(H,4,5,6)

InChI key

KIWUVOGUEXMXSV-UHFFFAOYSA-N

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General description

Rhodanine is a drug, which prevents the multiplication of echovirus 12.

Other Notes

Reagent for the gravimetric determination of silver; for the photometric determination of gallic acid

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

hazcat

Acute Tox. 4 Oral - Eye Irrit. 2

storage_class_code

11 - Combustible Solids

WGK Germany

WGK 3

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Selective inhibition of uncoating of echovirus 12 by rhodanine A study on early virus-cell interactions
Eggers, Hans J
Virology, 78(1), 241-252 (1977)
M. Thies et al.
Mikrochimica Acta, 809-809 (1973)
Parminder Singh et al.
Biochemistry, 51(27), 5434-5442 (2012-06-19)
A perturbation of FtsZ assembly dynamics has been shown to inhibit bacterial cytokinesis. In this study, the antibacterial activity of 151 rhodanine compounds was assayed using Bacillus subtilis cells. Of 151 compounds, eight strongly inhibited bacterial proliferation at 2 μM....
Tihomir Tomašić et al.
Expert opinion on drug discovery, 7(7), 549-560 (2012-05-23)
Rhodanine-based compounds have been associated with numerous biological activities. After many years of research in drug discovery, they have gained a reputation as being pan assay interference compounds (PAINS) and frequent hitters in screening campaigns. Rhodanine-based compounds are also aggregators...
Huan-qiu Li et al.
Bioorganic & medicinal chemistry, 20(14), 4194-4200 (2012-06-29)
A series of novel rhodanine-based acylsulfonamide derivatives were designed, synthesized, and evaluated as small-molecule inhibitors of anti-apoptotic Bcl-2 protein. These compounds exhibit potent antiproliferative activity in three human tumor cell lines (Hep G2, PC-3 and B16-F10). Among them, the most...

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