Sinapic acid

matrix substance for MALDI-MS, ≥99.0% (T)

Sinapinic acid, 3,5-Dimethoxy-4-hydroxycinnamic acid, 4-Hydroxy-3,5-dimethoxy-cinnamic acid
Empirical Formula (Hill Notation):
CAS Number:
Molecular Weight:
Beilstein/REAXYS Number:
EC Number:
MDL number:
PubChem Substance ID:

Quality Level


matrix substance for MALDI-MS


≥99.0% (T)

analyte chemical class(es)

dendrimers, fullerenes, peptides, proteins


MALDI-MS: suitable


slightly yellow


~202 °C


dioxane: 1 g/10 mL at Hot, clear, faintly yellow to dark yellow-orange
dioxane: 1 g/10 mL at Hot, clear, orange to very deep orange

cation traces

Ba: ≤5 mg/kg
Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤20 mg/kg
K: ≤50 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Na: ≤50 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Zn: ≤5 mg/kg


in accordance for UV test

SMILES string




InChI key


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General description

Sinapic acid is a type of phenolic acid. Removal of amino group from phenylalanine, catalysing with enzyme phenylalanine ammonia-lyase forms cinnamic acid. The precursor of hydroxycinnamates is produced after hydroxylation of benzene ring. One of the precursors produced is sinapic acid.


Sinapic acid was suitable as phenolic standard for HPLC analysis in determination of Sinapic acid derivatives in Canola extracts. 10 g/L of sinapinic acid with solvent was suitable as matrix for ultraviolet laser desorption mass spectrometric determination of proteins. It was also suitable to use as matrix for MALDI-TOFMS and MALDI-ion mobility-TOFMS to determine phospholipids in tissue.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. 85429.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.


Exclamation mark

Signal Word


Hazard Statements


Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system


11 - Combustible Solids

WGK Germany


Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Rabie Khattab et al.
Journal of the American Oil Chemists' Society, 87(2), 147-155 (2010-02-17)
A high-performance liquid chromatographic (HPLC) method with diode array detection (DAD) was used to determine the total phenolics, including sinapic acid derivatives in canola. Ten Western Canadian canola seeds, six other commodity canola seeds, their corresponding press cakes and meals...
Shelley N Jackson et al.
Journal of the American Society for Mass Spectrometry, 16(2), 133-138 (2005-02-08)
After water, lipids are the most common biomolecules found in the brain (12%). A brief perusal of the physiology, anatomy, and pathophysiology of the brain illustrates the importance of lipids. Recent advances in mass spectrometry have allowed the direct probing...
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Climate Change and Crops, 249-249 (2009)
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As reported here, we developed and optimized a purification matrix based on a Protein A-derived domain, ZCa, displaying calcium-dependent antibody binding. It provides an alternative to the acidic elution conditions of conventional Protein A affinity chromatography for purification of sensitive...
Yueming Hu et al.
Journal of Alzheimer's disease : JAD, 76(3), 883-893 (2020-06-23)
The mechanisms of how APOEɛ4 allele (APOE4) increases the risk of Alzheimer's disease (AD) pathology have not been fully elucidated. In cerebrospinal fluid (CSF), apoE is heavily glycosylated. To determine the impact of APOE genotype on the relative abundance of...

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