860867

Sigma-Aldrich

Brilliant Cresyl Blue ALD

Certified by the Biological Stain Commission

Synonym(s):
Brilliant Blue C, 3-Amino-7-(diethylamino)-2-methylphenoxazin-5-ium (T-4)-tetrachlorozincate (2:1)
Empirical Formula (Hill Notation):
C17H20ClN3O · 0.5ZnCl2
CAS Number:
Molecular Weight:
385.96
Beilstein/REAXYS Number:
5690713
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.47

Quality Level

form

powder or crystals

composition

Dye content, ≥50%

application(s)

hematology: suitable
histology: suitable

mp

233-236 °C (lit.)

λmax

622 nm

ε (extinction coefficient)

≥20000 at 237-241 nm in 50% ethanol at 0.005 g/L
≥20000 at 248-252 nm in 50% ethanol at 0.005 g/L

Featured Industry

Diagnostic Assay Manufacturing

storage temp.

room temp

SMILES string

[Cl-].[Cl-].Cl[Zn]Cl.CC\[N+](CC)=C1\C=CC2=Nc3cc(C)c(N)cc3OC2=C1.CC\[N+](CC)=C4\C=CC5=Nc6cc(C)c(N)cc6OC5=C4

InChI

1S/2C17H20N3O.4ClH.Zn/c2*1-4-20(5-2)12-6-7-14-16(9-12)21-17-10-13(18)11(3)8-15(17)19-14;;;;;/h2*6-10H,4-5,18H2,1-3H3;4*1H;/q2*+1;;;;;+2/p-4

InChI key

SIHASHFMDFXGSX-UHFFFAOYSA-J

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Related Categories

Application

Brilliant cresyl blue ALD has been used for the staining of reticulocytes.

Packaging

10, 25 g in glass bottle

Biochem/physiol Actions

Brilliant cresyl blue ALD is responsible for the staining of RNA in reticulocytes.

Other Notes

The structure of Brilliant Cresyl Blue ALD contains a 2-methyl modification on the phenoxazine core, while the structure of the historic Brilliant Cresyl Blue contains a 8-methyl modification on the phenoxazine core. The biological staining application is the same for both structures.

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Pal GK and Pal P
Textbook Of Practical Physiology (2006)
Inflammatory and oxidative stress phenotypes in transgenic sickle cell mice.
Charrin E, et al.
Blood Cells, Molecules and Diseases, 62, 13-13 (2016)
Clark, G., Ed.
Staining Procedures, 176-176 (1981)
A Zh Baltabekova et al.
Molecular biotechnology, 57(8), 746-755 (2015-04-04)
Immunoglobulin E (IgE) plays a central role in type I hypersensitivity including allergy and asthma. Novel treatment strategy envisages development of a therapeutic vaccine designed to elicit autologous blocking antibodies against the IgE. We sought to develop an IgE-epitope antigen...
Azza A G Tantawy et al.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 26(4), 419-425 (2015-02-24)
Endothelial nitric oxide synthase (eNOS), an enzyme that generates nitric oxide, is a major determinant of endothelial function. Several eNOS gene polymorphisms have been reported as 'susceptibility genes' in various human diseases states, including cardiovascular, pulmonary and renal diseases. We...

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