89803

Supelco

Methoxyamine hydrochloride

for GC derivatization, LiChropur, 97.5-102.5% (AT)

Synonym(s):
O-Methylhydroxylamine hydrochloride, Methoxylamine hydrochloride
Linear Formula:
CH3ONH2 · HCl
CAS Number:
Molecular Weight:
83.52
Beilstein/REAXYS Number:
3589723
MDL number:
NACRES:
NA.05

Quality Level

grade

for GC derivatization

assay

97.5-102.5% (AT)

quality

LiChropur

reaction suitability

reagent type: derivatization reagent
reaction type: Acylations

application(s)

gas chromatography (GC): suitable

mp

151-154 °C (lit.)

SMILES string

Cl.CON

InChI

1S/CH5NO.ClH/c1-3-2;/h2H2,1H3;1H

InChI key

XNXVOSBNFZWHBV-UHFFFAOYSA-N

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General description

Methoxyamine hydrochloride is a commonly used reagent for the generation of oxime derivatives of aldehyde- or ketone-group containing compounds. It is typically employed as an oximation reagent prior to silylation derivatizations.

Application

Methoxyamine hydrochloride can be used as:
  • A reagent for the preparation of O-methyl oximes.
  • A reagent used to make O-methyl oximes from aldehydes or ketones.
  • An alkylation reagent.
  • It may be used as a derivatization agent to improve the sensitivity of opioids, steroids and ionic metabolites in biological samples and non-volatile flavor compounds in "Angeleno" plum fruit prior to the determination of analytes using gas chromatography-mass spectrometry (GC-MS) technique.

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Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Signal Word

Danger

hazcat

Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Eye Irrit. 2 - Met. Corr. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 1

storage_class_code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

GC-MS analysis of multiply derivatized opioids in urine
Chen BG, et al.
Journal of Mass Spectrometry : Jms, 42(8), 1012-1023 (2007)
Solid-phase analytical derivatization for gas-chromatography-mass-spectrometry-based metabolomics
Takeo E, et al.
Journal of Bioscience and Bioengineering, 124(6), 700-706 (2017)
Microwave-assisted derivatization: application to steroid profiling by gas chromatography/mass spectrometry
Casals G, et al.
Journal of Chromatography. B, Biomedical Applications, 960(8), 8-13 (2014)
Optimization of Precolumn Derivatization for Simultaneous Gas Chromatography-Mass Spectrometric Analysis of Non-volatile Flavor Compounds in" Angeleno" Plum Fruit [J]
HU L, et al.
Food Science, 14(8), 8-13 (2010)
Data correction strategy for metabolomics analysis using gas chromatography-mass spectrometry.
Kanani HH and Klapa MI
Metabolic engineering, 9(1), 39-51 (2007)

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