90221

Retigabine

analytical standard

• Synonym(s): D-23129, Ezogabine, N-(2-Amino-4-(4-fluorobenzylamino)phenyl)carbamic acid ethyl ester
• Empirical Formula (Hill Notation): C₁₆H₁₈FN₃O₂
• CAS Number: 150812-12-7
• Molecular Weight: 303.33
• Beilstein/REAXYS Number: 8072099
• MDL number: MFCD04307735
• UNSPSC Code: 41116107
• PubChem Substance ID: 329769861
• NACRES: NA.24

Properties

• grade: analytical standard
• Quality Level: 100
• assay: ≥98.0% (HPLC)
• shelf life: limited shelf life, expiry date on the label
• drug control: USDEA Schedule IV
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• impurities: ≤1.0% water (calc. from elemental analysis)
• application(s): forensics and toxicology; veterinary
• format: neat
• storage temp.: 2-8°C
• SMILES string: FC1=CC=C(CNC2=CC(N)=C(NC(OCC)=O)C=C2)C=C1
• InChI: 1S/C16H18FN3O2/c1-2-22-16(21)20-15-8-7-13(9-14(15)18)19-10-11-3-5-12(17)6-4-11/h3-9,19H,2,10,18H2,1H3,(H,20,21)
• InChI key: PCOBBVZJEWWZFR-UHFFFAOYSA-N
• Gene Information: human ... KCNQ1(3784), KCNQ2(3785), KCNQ3(3786), KCNQ4(9132), KCNQ5(56479)

Description

General description

Retigabine is an antiepileptic drug, which activates neuronal KCNQ-type K+ channels by inducing a large hyperpolarizing shift of steady-state activation.[1][2]

Application

Retigabine may be used as a reference standard in the determination of retigabine in biological matrices using high-performance liquid chromatography coupled with tandem mass spectrometry with positive ion atmospheric pressure chemical ionization (HPLC-APCI-MS/MS).[3]

Biochem/physiol Actions

Retigabine (Ezogabine) is a Kv7.2-7.5 (KCNQ2-5) neuronal potassium channel opener witrh anticonvulsant activity.

Retigabine is a Kv7.2-7.5 potassium channel activator; anticonvulsant.

Safety Information

• pictograms: GHS06,GHS09
• signalword: Danger
• hcodes: H301 + H331,H410
• pcodes: P261 - P264 - P271 - P273 - P301 + P310 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable