909580

TIPS-5-Ethynyl-dU-CEP

• Synonym(s): TIPS-5-EdU CEP, TIPS-5-Ethynyl dU CEP, TIPS-5-Ethynyl dU phosphoramidite
• Empirical Formula (Hill Notation): C₅₀H₆₇N₄O₈PSi
• Molecular Weight: 911.15

Properties

• form: powder
• reaction suitability: reaction type: click chemistry
• mp: >300 °C
• storage temp.: −20°C

Description

Application

This functional phosphoramidite is used to introduce click handles universally (5′ internal and 3′ end) into oligonucleotides under standard conditions for solid phase synthesis. Afterwards the oligonucleotide (RNA, PNA, DNA) can be efficiently conjugated using a copper catalyzed click reaction to azide functionalized moieties such as fluorescent dye azides and azido amino acids. In contrast to 5-Ethynyl dU CEP, TIPS-5-EdU CEP allows side product free synthesis of highly modified oligonucleotides (>10 modifications).

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable