91275

Propionyl-L-carnitine

analytical standard

• Synonym(s): (2R)-3-Carboxy-N,N,N-trimethyl-2-(1-oxopropoxy)-1-propanaminium inner salt, L-Carnitine propionyl ester, C3-Carnitine, Propanoyl-L-carnitine
• Empirical Formula (Hill Notation): C₁₀H₁₉NO₄
• CAS Number: 20064-19-1
• Molecular Weight: 217.26
• MDL number: MFCD00870024
• NACRES: NB.21

Properties

• grade: analytical standard
• Quality Level: 100
• Assay: ≥94.0% (HPLC)
• optical activity: [α]/D -24.0±2.0°, c = 0.2 in H₂O
• shelf life: limited shelf life, expiry date on the label
• impurities: ≤13% water ((calculated from elemental analysis)
• application(s): clinical testing
• format: neat
• storage temp.: 2-8°C
• SMILES string: [O-]C(C[C@@H](OC(CC)=O)C[N+](C)(C)C)=O
• InChI: 1S/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3/t8-/m1/s1
• InChI key: UFAHZIUFPNSHSL-MRVPVSSYSA-N

Description

General description

Propionyl-L-carnitine (PLC), a natural odd-carbon-number, endogenous ester of L-carnitine, is found to be present in humans and animals as a minor component compared to L-carnitine (LC) and acetyl-L-carnitine (ALC). It acts as a carrier of long chain acyl groups from activated fatty acids across the inner mitochondrial membrane into the mitochondrial matrix where they undergo β-oxidation to acetyl CoA to obtain usable energy via the citric acid cycle.

Application

Propionyl-L-carnitine may be used as an analytical reference standard for the quantification of the analyte in biological samples using chromatography-based techniques. It may also be used as an analytical standard in monitoring the analyte in chemical synthesis procedures and pharmaceutical formulations using a stereospecific enzyme assay and high-performance liquid chromatography technique with UV detection.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable