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91275

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Propionyl-L-carnitine

analytical standard

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Synonym(s):
(2R)-3-Carboxy-N,N,N-trimethyl-2-(1-oxopropoxy)-1-propanaminium inner salt, L-Carnitine propionyl ester, C3-Carnitine, Propanoyl-L-carnitine
Empirical Formula (Hill Notation):
C10H19NO4
CAS Number:
Molecular Weight:
217.26
MDL number:
NACRES:
NB.21

grade

analytical standard

Quality Level

assay

≥94.0% (HPLC)

optical activity

[α]/D -24.0±2.0°, c = 0.2 in H2O

shelf life

limited shelf life, expiry date on the label

impurities

≤13% water ((calculated from elemental analysis)

application(s)

clinical testing

format

neat

storage temp.

2-8°C

SMILES string

[O-]C(C[C@@H](OC(CC)=O)C[N+](C)(C)C)=O

InChI

1S/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3/t8-/m1/s1

InChI key

UFAHZIUFPNSHSL-MRVPVSSYSA-N

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This Item
915034260252941
Propionyl-L-carnitine analytical standard

91275

Propionyl-L-carnitine

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91503

Palmitoyl-L-carnitine

Propionyl-L-carnitine ≥94.0% (HPLC)

42602

Propionyl-L-carnitine

Propionyl-L-carnitine-(N-methyl-d3) analytical standard

52941

Propionyl-L-carnitine-(N-methyl-d3)

grade

analytical standard

grade

analytical standard

grade

-

grade

analytical standard

assay

≥94.0% (HPLC)

assay

≥95.0% (HPLC)

assay

≥94.0% (HPLC)

assay

≥97.0% (TLC)

optical activity

[α]/D -24.0±2.0°, c = 0.2 in H2O

optical activity

[α]/D -17.0±2.0°, c = 1 in methanol

optical activity

[α]/D -23±3°, c = 1 in H2O

optical activity

[α]/D -22±2°, c = 0.1 in H2O

shelf life

limited shelf life, expiry date on the label

shelf life

limited shelf life, expiry date on the label

shelf life

-

shelf life

limited shelf life, expiry date on the label

impurities

≤13% water ((calculated from elemental analysis)

impurities

≤10% water

impurities

≤10% water (calcd. from elemental analysis)

impurities

-

General description

Propionyl-L-carnitine (PLC), a natural odd-carbon-number, endogenous ester of L-carnitine, is found to be present in humans and animals as a minor component compared to L-carnitine (LC) and acetyl-L-carnitine (ALC). It acts as a carrier of long chain acyl groups from activated fatty acids across the inner mitochondrial membrane into the mitochondrial matrix where they undergo β-oxidation to acetyl CoA to obtain usable energy via the citric acid cycle.

Application

Propionyl-L-carnitine may be used as an analytical reference standard for the quantification of the analyte in biological samples using chromatography-based techniques. It may also be used as an analytical standard in monitoring the analyte in chemical synthesis procedures and pharmaceutical formulations using a stereospecific enzyme assay and high-performance liquid chromatography technique with UV detection.

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Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Levocarnitine Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1569

Levocarnitine

Determination of L-carnitine, acetyl-L-carnitine and propionyl-L-carnitine in human plasma by high-performance liquid chromatography after pre-column derivatization with 1-aminoanthracene
Longo A, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 686(2), 129-139 (1996)
Quantitation of L?carnitine, acetyl?L?carnitine, propionyl?L?carnitine and their deuterated analogues by high?performance liquid chromotography tandem mass spectrometry
Tallarico C , et al.
Rapid Communications in Mass Spectrometry, 12(7), 403-409 (1998)
Application of high-performance liquid chromatography to the analysis of propionyl-L-carnitine by a stereospecific enzyme assay
Marzo A, et al.
Journal of Chromatography A, 459, 313-317 (1988)

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