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91503

Supelco

Palmitoyl-L-carnitine

analytical standard

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Synonym(s):
(2R)-3-Carboxy-N,N,N-trimethyl-2-[(1-oxohexadecyl)oxy]-1-propanaminium inner salt, L-Carnitine hexadecanoyl ester, C16-Carnitine, Hexadecanoyl-L-carnitine
Empirical Formula (Hill Notation):
C23H45NO4
CAS Number:
Molecular Weight:
399.61
Beilstein:
4152034
NACRES:
NB.21

grade

analytical standard

Quality Level

Assay

≥95.0% (HPLC)

optical activity

[α]/D -17.0±2.0°, c = 1 in methanol

shelf life

limited shelf life, expiry date on the label

impurities

≤10% water

application(s)

clinical testing

format

neat

storage temp.

2-8°C

SMILES string

C[N+](C)(C)C[C@H](OC(CCCCCCCCCCCCCCC)=O)CC([O-])=O

InChI

1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m1/s1

InChI key

XOMRRQXKHMYMOC-OAQYLSRUSA-N

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This Item
612519127555107
Palmitoyl-L-carnitine analytical standard

Supelco

91503

Palmitoyl-L-carnitine

Palmitoyl-L-carnitine ≥97.0% (HPLC)

Sigma-Aldrich

61251

Palmitoyl-L-carnitine

Propionyl-L-carnitine analytical standard

Supelco

91275

Propionyl-L-carnitine

format

neat

format

-

format

neat

format

neat

assay

≥95.0% (HPLC)

assay

≥97.0% (HPLC)

assay

≥94.0% (HPLC)

assay

≥97.0% (TLC)

optical activity

[α]/D -17.0±2.0°, c = 1 in methanol

optical activity

[α]/D -17±2°, c = 1 in methanol

optical activity

[α]/D -24.0±2.0°, c = 0.2 in H2O

optical activity

[α]/D -15.0±2.0°, c = 0.1 in methanol

shelf life

limited shelf life, expiry date on the label

shelf life

-

shelf life

limited shelf life, expiry date on the label

shelf life

limited shelf life, expiry date on the label

impurities

≤10% water

impurities

≤10% water

impurities

≤13% water ((calculated from elemental analysis)

impurities

-

General description

Palmitoyl-L-carnitine (PLC) belongs to the class of long chain acylcarnitine compounds. It is an acyl-chain ester, which can be obtained from L-carnitine via acylcarnitine family transferase. PLC is reported to be used for the phospholipid reacylation in erythrocyte membrane ghosts.

Application

Palmitoyl-L-carnitine may be used as an analytical standard to quantify the analyte in biological samples of patients with continuous ambulatory peritoneal dialysis (CAPD) or automated peritoneal dialysis (APD) using high-performance liquid chromatography/tandem quadrupole mass spectrometry (HPLC-TQMS). The feasibility of adding L-carnitine to the peritoneal dialysis (PD) solution in APD-treated end-stage renal disease patients is investigated. It may also be used as an analytical reference standard for the separation and identification of underivatized palmitoyl-L-carnitine in human plasma samples using high-performance liquid chromatography coupled to tandem mass spectrometry (HPLC-MS/MS).

Recommended products

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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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08984

Butyryl-L-carnitine

Octanoyl-L-carnitine ≥97.0% (TLC)

Sigma-Aldrich

50892

Octanoyl-L-carnitine

L-Carnitine hydrochloride analytical standard

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L-Carnitine hydrochloride

L-Carnitine inner salt synthetic, ≥98%

Sigma-Aldrich

C0158

L-Carnitine inner salt

Role of carnitine and carnitine palmitoyltransferase as integral components of the pathway for membrane phospholipid fatty acid turnover in intact human erythrocytes
Arduini A, et al.
The Journal of Biological Chemistry, 267(18), 12673-12681 (1992)
L-Carnitine status in end-stage renal disease patients on automated peritoneal dialysis
Liberato DL , et al.
Journal of Nephrology, 27(6), 699-706 (2014)
Minzhi Peng et al.
Journal of chromatography. A, 1319, 97-106 (2013-10-31)
A simple HPLC-MS/MS method has been established to separate and identify underivatized acylcarnitine isomers. Human plasma samples were deproteinized and concentrated. Acylcarnitines were separated on a reverse phase column and detected with triple quadrupole linear ion trap mass spectrometry. Deuterium-labeled

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