91503

Supelco

Palmitoyl-L-carnitine

analytical standard

Synonym(s):
(2R)-3-Carboxy-N,N,N-trimethyl-2-(1-oxohexadecyl)oxy-1-propanaminium inner salt, C16-Carnitine, Hexadecanoyl-L-carnitine, L-Carnitine hexadecanoyl ester
Empirical Formula (Hill Notation):
C23H45NO4
CAS Number:
Molecular Weight:
399.61
Beilstein/REAXYS Number:
4152034
NACRES:
NB.21
Pricing and availability is not currently available.

grade

analytical standard

Quality Level

assay

≥95.0% (HPLC)

optical activity

α/D -17.0±2.0°, c = 1 in methanol

CofA

certificate is enclosed in each package

shelf life

limited shelf life, expiry date on the label

impurities

≤10% water

format

neat

storage temp.

2-8°C

SMILES string

CN+(C)(C)CC@H(OC(CCCCCCCCCCCCCCC)=O)CC(O-)=O

InChI

1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m1/s1

InChI key

XOMRRQXKHMYMOC-OAQYLSRUSA-N

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General description

Palmitoyl-L-carnitine (PLC) belongs to the class of long chain acylcarnitine compounds. It is an acyl-chain ester, which can be obtained from L-carnitine via acylcarnitine family transferase. PLC is reported to be used for the phospholipid reacylation in erythrocyte membrane ghosts.

Application

Palmitoyl-L-carnitine may be used as an analytical standard to quantify the analyte in biological samples of patients with continuous ambulatory peritoneal dialysis (CAPD) or automated peritoneal dialysis (APD) using high-performance liquid chromatography/tandem quadrupole mass spectrometry (HPLC-TQMS). The feasibility of adding L-carnitine to the peritoneal dialysis (PD) solution in APD-treated end-stage renal disease patients is investigated. It may also be used as an analytical reference standard for the separation and identification of underivatized palmitoyl-L-carnitine in human plasma samples using high-performance liquid chromatography coupled to tandem mass spectrometry (HPLC-MS/MS).

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Target Organs

Respiratory system

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Role of carnitine and carnitine palmitoyltransferase as integral components of the pathway for membrane phospholipid fatty acid turnover in intact human erythrocytes
Arduini A, et al.
The Journal of Biological Chemistry, 267(18), 12673-12681 (1992)
L-Carnitine status in end-stage renal disease patients on automated peritoneal dialysis
Liberato DL , et al.
Journal of Nephrology, 27(6), 699-706 (2014)
Minzhi Peng et al.
Journal of chromatography. A, 1319, 97-106 (2013-10-31)
A simple HPLC-MS/MS method has been established to separate and identify underivatized acylcarnitine isomers. Human plasma samples were deproteinized and concentrated. Acylcarnitines were separated on a reverse phase column and detected with triple quadrupole linear ion trap mass spectrometry. Deuterium-labeled...

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