MilliporeSigma
All Photos(6)

920207

Sigma-Aldrich

Cyrene γ-Valerolactone Blend

greener alternative

BioRenewable

Synonym(s):
γ-Valerolactone Cyrene solution, γ-Valerolactone solution, Cyrene solution, Cyrene γ-valerolactone solution
Empirical Formula (Hill Notation):
C6H8O3
Molecular Weight:
128.13

form

liquid

greener alternative product characteristics

Safer Solvents and Auxiliaries
Use of Renewable Feedstocks
Learn more about the Principles of Green Chemistry.

renewable carbon content

100%

density

1.141 g/mL

greener alternative category

General description

Cyrene γ-Valerolactone Blend is specially formulated for use in automated processes and applications where lower viscosity is required, making it easier to handle while maintaining high yields.

This Cyrene blend is an alternative for NMP and DMF in many cross-coupling reactions. Neither Cyrene nor γ-Valerolactone have any genotoxic or mutagenic concerns associated with their use, making them much safer alternatives to traditional aprotic solvents.

This new blend is part of our Biorenewable product line, meaning that it is made from renewable resources and does not compete with food resources for its production, making it more environmentally sustainable for the future. The material has also been independently certified as 100% renewable carbon.

Application

This cosolvent solution has been shown to have similar reaction yields to NMP and DMF for many cross-coupling reactions, such as:
  • HATU Amide Coupling - Replacement for DMF in amide and dipeptide coupling reactions
  • Suzuki-Miyaura coupling reaction
  • Sonogashira coupling reaction

Features and Benefits

  • Independently certified as 100% renewable carbon.
  • Closer physical properties of NMP and DMF while maintaining high reaction yields.
  • Sustainably produced and environmentally less hazardous than more traditional petroleum aprotic solvents
  • Both Cyrene and GVL are also much safer for handling without the genotoxic concerns of other solvents.
  • It has a lower viscosity than neat Cyrene making it more optimized for automated processes.

Legal Information

CYRENE is a trademark of Circa Group Pvt Ltd

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service