If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf
92360
Chlorotrimethylsilane
puriss., ≥99.0% (GC)
Synonym(s):
TMCS, Trimethylchlorosilane, Trimethylsilyl chloride
Select a Size
$33.80
$91.30
$252.00
$33.80
Available to ship TODAYDetails
About This Item
Skip To
Product Name
Chlorotrimethylsilane, puriss., ≥99.0% (GC)
SMILES string
[H][C@@]12CC(C)(C)CC[C@]1(C)CC[C@]3(C)C2=CC[C@]4([H])[C@@]5(C)CC[C@H](O)C(C)(C)[C@]5([H])CC[C@@]34C
C[Si](C)(C)Cl
InChI key
IJOOHPMOJXWVHK-UHFFFAOYSA-N
InChI
1S/C3H9ClSi/c1-5(2,3)4/h1-3H3
vapor density
3.7 (vs air)
vapor pressure
100 mmHg ( 25 °C)
grade
puriss.
assay
≥99.0% (GC)
form
liquid
autoignition temp.
752 °F
expl. lim.
6.4 %
refractive index
n20/D 1.387 (lit.)
bp
57 °C (lit.)
mp
−40 °C (lit.)
density
0.856 g/mL at 25 °C (lit.)
Quality Level
Looking for similar products? Visit Product Comparison Guide
1 of 4
This Item | 95541 | 89595 | 384410 |
|---|---|---|---|
| assay ≥99.0% (GC) | assay ≥99.0% (GC) | assay ≥99.0% (GC) | assay - |
| Quality Level 200 | Quality Level 200 | Quality Level 100 | Quality Level 100 |
| mp −40 °C (lit.) | mp −40 °C (lit.) | mp −40 °C (lit.) | mp - |
| bp 57 °C (lit.) | bp 57 °C (lit.) | bp 57 °C (lit.) | bp - |
| form liquid | form liquid | form liquid | form liquid |
| refractive index n20/D 1.387 (lit.) | refractive index n20/D 1.387 (lit.) | refractive index n20/D 1.387 (lit.) | refractive index - |
Application
- Chlorotrimethylsilane can be a non-toxic alternative to mercuric chloride as activator in samarium-promoted cyclopropanation of both allylic and α-allenic alcohols.[1]
- It can be used in combination with hexamethyldisilazane for the protection of alcohols by forming trimethylsilyl ethers via silylation.[2]
- It is employed in chloromethylation of polysulfones (PSUs).[3]
- It activates lithium hydride to convert it into a hydride source for the reductive silylation of carbonyl compounds.[4]
- Chlorotrimethylsilane/lithium bromide forms an effective reagent for the conversion of alcohols to bromides.[5]
- Chlorotrimethylsilane/sodium iodide in acetonitrile is a better alternative to iodotrimethylsilane for the cleavage of esters, lactones, carbamates, and ethers. It can also be used for the conversion of alcohols to iodides.[6]
- Chlorotrimethylsilane along with silver or ammonium nitrate forms an efficient regioselective nitrating reagent for the ipso-nitration of arylboronic acids to form the corresponding nitroarenes.[7]
- Chlorotrimethylsilane along with sodium nitrite or nitrate can be used for deoximation reactions.[8]
General description
signalword
Danger
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1A
supp_hazards
Storage Class
3 - Flammable liquids
wgk
WGK 1
flash_point_f
-18.4 °F - closed cup
flash_point_c
-28 °C - closed cup
ppe
Faceshields, Gloves, Goggles
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Articles
Results of a study involving the ability few Fluka silylating reagents to form GC-MS-compatible trimethylsilylmethyl derivatives of NSAIDs
-
How can I determine the shelf life / expiration / retest date of this product?
1 answer-
Helpful?
-
-
How is shipping temperature determined? And how is it related to the product storage temperature?
1 answer-
Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
Helpful?
-
Active Filters
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service