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92822

Sigma-Aldrich

Picrylsulfonic acid solution

1 M in H2O

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Synonym(s):
2,4,6-Trinitrobenzenesulfonic acid solution, TNBS
Empirical Formula (Hill Notation):
C6H3N3O9S
CAS Number:
Molecular Weight:
293.17
Beilstein:
572358
MDL number:
PubChem Substance ID:
NACRES:
NA.25

form

liquid

Quality Level

concentration

1 M in H2O

density

1.14 g/mL at 20 °C

ε (extinction coefficient)

≤0.85 at 340 nm

shipped in

dry ice

storage temp.

−20°C

SMILES string

OS(=O)(=O)c1c(cc(cc1[N+]([O-])=O)[N+]([O-])=O)[N+]([O-])=O

InChI

1S/C6H3N3O9S/c10-7(11)3-1-4(8(12)13)6(19(16,17)18)5(2-3)9(14)15/h1-2H,(H,16,17,18)

InChI key

NHJVRSWLHSJWIN-UHFFFAOYSA-N

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1 of 4

This Item
P2297P6744702722
Picrylsulfonic acid solution 5 % (w/v) in H2O, BioReagent, suitable for determination of primary amines

Sigma-Aldrich

P2297

Picrylsulfonic acid solution

Essential+ Grade
Picric acid solution 1.3% in H2O (saturated)

Sigma-Aldrich

P6744

Picric acid solution

-
concentration

1 M in H2O

concentration

5 % (w/v) in H2O

concentration

1.3% in H2O (saturated)

concentration

1 M in THF

density

1.14 g/mL at 20 °C

density

-

density

1.080 g/cm3

density

0.915 g/mL at 25 °C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

room temp

storage temp.

-

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

ε (extinction coefficient)

≤0.85 at 340 nm

ε (extinction coefficient)

-

ε (extinction coefficient)

-

ε (extinction coefficient)

-

Application

Hydrophilic modifying reagent. Derivatives with amino compounds can be regenerated with hydrazine.
Picrylsulfonic acid (2,4,6-Trinitrobenzenesulfonic acid solution, TNBS) may be used in studies on the mechanisms of intracellular pH regulation. TNBS is used to induce inflammatory bowel disease (IBD)/colonic inflammation for studies on its mechanism and treatment.

Caution

decomposes when stored at temperatures ≥0°C with precipitate formation (picric acid)

Other Notes

Sales restrictions may apply

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Desen. Expl. 3 - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Øystein Brenna et al.
PloS one, 8(1), e54543-e54543 (2013-02-06)
Rectal instillation of trinitrobenzene sulphonic acid (TNBS) in ethanol is an established model for inflammatory bowel disease (IBD). We aimed to 1) set up a TNBS-colitis protocol resulting in an endoscopic and histologic picture resembling IBD, 2) study the correlation
Ana Beatriz Albino de Almeida et al.
Journal of ethnopharmacology, 146(1), 300-310 (2013-01-15)
In Brazilian traditional medicine, Arctium lappa (Asteraceae), has been reported to relieve gastrointestinal symptoms. In the present study, we investigated the effects of the lactone sesquiterpene onopordopicrin enriched fraction (ONP fraction) from Arctium lappa in an experimental colitis model induced
Weicheng Liu et al.
The Journal of clinical investigation, 123(9), 3983-3996 (2013-08-16)
The inhibitory effects of vitamin D on colitis have been previously documented. Global vitamin D receptor (VDR) deletion exaggerates colitis, but the relative anticolitic contribution of epithelial and nonepithelial VDR signaling is unknown. Here, we showed that colonic epithelial VDR
Zhen Huang et al.
Gut, 63(8), 1247-1257 (2013-09-04)
Emerging evidence suggests that microRNA (miRNA)-mediated gene regulation influences a variety of autoimmune disease processes, including Crohn's disease (CD), but the biological function of miRNAs in CD remains unclear. We examine miRNA level in colon tissues and study the potential
Bas Kremer et al.
PloS one, 7(11), e50388-e50388 (2012-12-12)
The recurrent TNBS-colitis model in BALB/c mice has been proposed as a model of Inflammatory Bowel Disease with a shifting pattern of local cytokines with the expression of Th1 cytokines during the early phase, Th17 cytokines during the intermediate phase

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