96408

Supelco

N-(2-Phenylacetyl)glycine

analytical standard

Synonym(s):
NSC 92778, 2-Phenylacetyl glycine, 2-(2-Phenylacetamido)acetic acid, Phenacetylglycine, NSC 408424, Phenaceturic acid
Empirical Formula (Hill Notation):
C10H11NO3
CAS Number:
Molecular Weight:
193.20
Beilstein/REAXYS Number:
1107116
MDL number:
PubChem Substance ID:
NACRES:
NA.24
Pricing and availability is not currently available.

grade

analytical standard

Quality Level

assay

≥98.0% (HPLC)

CofA

certificate is enclosed in each package

shelf life

limited shelf life, expiry date on the label

format

neat

storage temp.

2-8°C

InChI

1S/C10H11NO3/c12-9(11-7-10(13)14)6-8-4-2-1-3-5-8/h1-5H,6-7H2,(H,11,12)(H,13,14)

InChI key

UTYVDVLMYQPLQB-UHFFFAOYSA-N

Biochem/physiol Actions

Phenylacetylglycine is an acylglycine. Acylglycines are normally minor metabolites of fatty acids. However, the excretion of certain acylglycines is increased in several inborn errors of metabolism. In certain cases the measurement of these metabolites in body fluids can be used to diagnose disorders associated with mitochondrial fatty acid beta-oxidation. Acylglycines are produced through the action of glycine N-acyltransferase (EC 2.3.1.13) which is an enzyme that catalyzes the chemical reaction: acyl-CoA + glycine ↔ CoA + N-acylglycine. Phenylacetylglycine or PAG is a glycine conjugate of phenylacetic acid. Phenylacetic acid may arise from exposure to styrene (plastic) or through the consumption of fruits and vegetables. Phenylacetic acid is used in some perfumes, possessing a honey-like odour in low concentrations, and is also used in penicillin G production. PAG is a putative biomarker of phospholipidosis. Urinary PAG is elevated in animals exhibiting abnormal phospholipid accumulation in many tissues and may thus be useful as a surrogate biomarker for phospholipidosis. The presence of phenylacetylglycine in urine has been confirmed for dogs, rats and mice. However, the presence of this compound in human urine is controversial. GC-MS studies have not found this compound while NMR studies claimed to have identified it , It appears that phenylacetylglycine may sometimes be mistaken for phenylacetylglutamine via NMR.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
M Matsumoto et al.
The Journal of veterinary medical science, 57(2), 205-211 (1995-04-01)
After the urine was treated with urease, lyophilized, and trimethylsilylated, it was examined for metabolic profiles in Dalmatian dogs and Shetland sheepdogs by gas chromatography-mass spectrometry (GC/MS), which simultaneously analyzes organic acids, amino acids, sugars, sugar alcohols, purine and pyrimidine...
Hudan Pan et al.
Frontiers of medicine, 13(5), 564-574 (2019-05-16)
Traditional Chinese medicine (TCM) formulas have attracted increasing attention worldwide in the past few years for treating complex disease including rheumatoid arthritis. However, their mechanisms are complex and remain unclear. Guan-Jie-Kang (GJK), a prescription modified from "Wu Tou Decoction," was...
Jane Delaney et al.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 9(3), 271-290 (2005-03-15)
Amiodarone was given to male Sprague-Dawley rats at a dose of 150 mg kg(-1) day(-1) for 7 consecutive days to induce phospholipidosis in the lungs of treated rats. Amiodarone was given alone or concurrently with phenobarbitone. Animals given amiodarone had...
Xiuting Yu et al.
Experimental and therapeutic medicine, 14(2), 1184-1192 (2017-08-16)
The incidence of inflammatory bowel disease (IBD), characterized by chronic, relapsing intestinal inflammation, has continually increased in recent years. A previous study by our group identified five potential metabolic markers possibly associated with the pathology of 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced IBD...
Resistant Starch but Not Enzymatically Modified Waxy Maize Delays Development of Diabetes in Zucker Diabetic Fatty Rats.
Mette Skou Hedemann et al.
The Journal of nutrition, 147(5), 825-834 (2017-03-17)

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